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Cancer Epigenetics

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This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.


Part I: Background: Epigenetic Mechanism

1. Cancer Epigenetics: An Introduction

Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta

2. Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program

John S. Satterlee, Andrea Beckel-Mitchener, Kim McAllister, Dena C. Procaccini, Joni L. Rutter, Frederick L. Tyson, and Lisa Helbling Chadwick

3. Epigenome-Wide Association Studies (EWAS): Past, Present, and Future

James M. Flanagan

4. Epigenetic Biomarkers in Liver Cancer

Krishna K. Banaudha and Mukesh Verma

Part II: Cancer Specific Type Epigenetic Changes

5. Cancer Type Specific Epigenetic Changes: Gastric Cancer

Danielle Queiroz Calcagno, Marília de Arruda Cardoso Smith, and Rommel Rodriguez Burbano

6. Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer

Andrea J. Savio and Bharati Bapat

7. Prostate Cancer Epigenome

Swathi Chinaranagari, Pankaj Sharma, Nathan J. Bowen, and Jaideep Chaudhary

8. CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer

Yujin Kim and Duk-Hwan Kim

9. Analysis of DNA Methylation in Pancreatic Cancer: An Update

Christian Pilarsky and Robert Grützmann

10. Epigenetics of Urothelial Carcinoma

Wolfgang A. Schulz, Evangelia A. Koutsogiannouli, Günter Niegisch, and Michèle J. Hoffmann

11. Epigenetics of Prostate Cancer

Tawnya C. McKee and James V. Tricoli

12. Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options

Xinbo Zhang, Naimei Tang, Arun K. Rishi, Harvey I. Pass, and Anil Wali

Part III: Methods and Technologies Used for Detecting Epigenetic Changes

13. Techniques to Access Histone Modifications and Variants in Cancer

Monica Tyagi, Shafqat A Khan, Saikat Bhattacharya, Divya Reddy, Ajit K Sharma, Bharat Khade, and Sanjay Gupta

14. Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS

Maria A. Hahn, Arthur X. Li, Xiwei Wu, and Gerd P. Pfeifer

15. Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer

Atsushi Kaneda and Koichi Yagi

16. Histone Modifications Associated with Cancer Cell Migration and Invasion

Miki Hieda, Nariaki Matsuura, and Hiroshi Kimura

Part IV: Factors that Influence Epigenetic Changes in Cancer

17. Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers

Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan

18. Cancer-Associated Infectious Agents and Epigenetic Regulation

Vidya Vedham and Mukesh Verma

19. Toxicoepigenomics and Cancer: Implications for Screening

Mukesh Verma

20. Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome

Josena K. Stephen and Maria J. Worsham

21. Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies

Mukesh Verma

22. Epigenetics of Colorectal Cancer

Wenji Yan and Mingzhou Guo

23. Epigenetics in Breast and Prostate Cancer

Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama

Part V: Future Directions: Risk Assessment, Diagnosis, Treatment, and Prognosis

24. Epigenetic Inhibitors

Mukesh Verma and Hirendra Nath Banerjee

25. Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies

Aurore Claude-Taupin, Michael Boyer-Guittaut, Régis Delage-Mourroux, and Eric Hervouet

26. Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis

Gwyneth Hyman, Vinod Manglik, Jeffrey M. Rousch, Mukesh Verma, David Kinkebiel, and Hirendra Nath Banerjee

27. Detection of Circulatory MicroRNAs in Prostate Cancer

Anvesha Srivastava, Helle Goldberger, Zainab Afzal, Simeng Suy, Sean P. Collins, and Deepak Kumar

28. Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases

Daiqing Liao

29. Epigenetic Regulation in Biopsychosocial Pathways

Kristin Litzelman and Mukesh Verma

30. Viral Epigenetics

Barry I. Milavetz and Lata Balakrishnan

31. P53 Tumor Suppression Network in Cancer Epigenetics

Alok Mishra, Daniel J. Brat, and Mukesh Verma

32. Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma

Jong Y. Park

33. Sequencing the Cancer Methylome

Austin Y. Shull, Satish K. Noonepalle, Eun-Joon Lee, Justin Choi, and Huidong Shi

34. Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome

Jessica Tang, Fang Fang, Dave F. Miller, Jay M. Pilrose, Daniela Matei, Tim H.-M. Huang, and Kenneth P. Nephew

35. Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer

Sharad K. Verma

36. At the Crossroad Between Obesity and Gastric Cancer

Robert B. Uddo, Jone Garai, Maura C. Mohler, Nicole Pelligrino, Richard Scribner, Melinda S. Sothern, and Jovanny Zabaleta

37. Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma

Yujing Zhang

38. Specific Type Epigenetic Changes in Cervical Cancers

Shuping Zhao

39. Epigenetics in Head and Neck Cancer

Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh

40. Epigenetic Therapy for Colorectal Cancer

Vivek Vaish, Tripti Khare, Mukesh Verma, and Sharad Khare


Titel: Cancer Epigenetics
Untertitel: Risk Assessment, Diagnosis, Treatment, and Prognosis
EAN: 9781493918034
ISBN: 978-1-4939-1803-4
Format: Fester Einband
Genre: Medizin
Anzahl Seiten: 804
Gewicht: g
Größe: H35mm x B259mm x T183mm
Jahr: 2015
Auflage: 2015



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