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Cancer Biology and the Nuclear Envelope

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quot;Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years... Weiterlesen
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quot;Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."


Eric C. Schirmer, Ph.D., Wellcome Trust Senior Research Fellow, Wellcome Trust Centre for Cell Biology and Reader, Institute of Cell Biology at the University of Edinburgh. Jose de las Heras Ph.D., Researcher at the University of Edinburgh.


Section I: History and use of the nuclear envelope in cancer prognosis

Chapter 1: Cancer and the nuclear envelope, a history and perspective - Jose de las Heras and Eric C. Schirmer, Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK

Chapter 2: The role of the nuclear lamina in cancer and apoptosis - Jos L.V. Broers and Frans C.S. Ramaekers, GROW - School of Oncology and Developmental Biology, Department of Molecular Cell Biology, Maastricht University, Netherlands

Chapter 3: The diagnostic pathology of the nuclear envelope in human cancers - Andrew H. Fischer, Department of Pathology, University of Massachusetts Memorial Medical Center, USA

Chapter 4: Nuclear morphometry, epigenetic changes, and clinical relevance in prostate cancer - Robert W. Veltri and Christhunesa S. Christudass, The Brady Urological Research Institute, Johns Hopkins Hospital, USA

Chapter 5: "To be or not to be in a good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer - Gianni Bussolati, Francesca Maletta, Sofia Asioli, Laura Annaratone, Anna Sapino, and Caterina Marchio, Department of Medical Sciences, University of Turin, Italy and Institut Victor Babes, Romania

Section II: The nuclear envelope in cell cycle regulation and signaling

Chapter 6: pRb and lamins in cell cycle regulation and aging - Brian K. Kennedy and Juniper K. Pennypacker, Buck Institute for Research on Aging, USA

Chapter 7: Lamina-associated polypeptide (LAP)2a and other LEM proteins in cancer biology - Andreas Brachner and Roland Foisner, Max F. Perutz Laboratories, Medical University Vienna, Austria

Chapter 8: NETs and cell cycle regulation - Michael I. Robson, Phu Le Thanh and Eric C. Schirmer, Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK

Chapter 9: Nuclear envelope regulation of signaling cascades - Jason C. Choi and Howard J. Worman, Department of Medicine and Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, USA

Section III: Nuclear envelope regulation of the genome

Chapter 10: Nuclear envelope - connecting structural genome organization to regulation of gene expression - Irina Stancheva and Eric C. Schirmer, Wellcome Trust Centre for Cell Biology, University of Edinburgh

Chapter 11: Studying lamins in invertebrate models - Roman Lyakhovetsky and Yosef Gruenbaum, Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Israel

Chapter 12: Lamin organization of chromosome positioning - Joanna M. Bridger, Halime D. Arican-Gotkas, Helen A. Foster, Lauren S. Godwin, Amanda Harvey, Ian R. Kill, Matty Knight, Ishita S. Mehta, and Mai Hassan Ahmed, Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Biosciences, School of Health Sciences, Brunel University, UK, Institute for Cancer Genetics and Pharmacogenomics, Biosciences, Brunel University, UK, 3Biomedical Sciences Research Centre, University of London, UK, 4Department of Microbiology, Immunology & Tropical Medicine, The George Washington University, USA

Section IV: Functions of the NPC in cancer

Chapter 13: NPC proteins linked to cancer overview - Dan N. Simon and Michael P. Rout, Rockefeller University, USA

Chapter 14: Roles of the nucleoporin Tpr in cancer and aging - Chelsi J. Snow and Bryce M. Paschal, Center for Cell Signaling and Department of Biochemistry and Molecular Genetics, University of Virginia, USA

Chapter 15: Ran GTPase in nuclear envelope formation and cancer metastasis - Kyle B. Matchett, Suzanne McFarlane, Sophie E. Hamilton, Yousef S. A. Eltuhamy, Matthew A. Davidson, James T. Murray, Ahmed M. Faheem and Mohamed El-Tanani, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Trinity Biomedical Sciences Institute, Trinity College Dublin, and School of Pharmacy and Pharmaceutical Science, University of Ulster, Ireland

Chapter 16: Wnt signaling proteins associate with the nuclear pore complex: implications for cancer - Manisha Sharma, Michael Johnson, Mariana Brocardo, Cara Jamieson and Beric R. Henderson, Westmead Institute for Cancer Research, The University of Sydney, Westmead Millennium Institute at Westmead Hospital, Australia

Section V: The nuclear envelope in DNA damage and stress responses

Chapter 17: DNA damage and lamins - Susana Gonzalo, Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, USA

Chapter 18: Repo-Man at the intersection of chromatin remodeling, DNA repair, nuclear envelope organization and cancer progression - Paola Vagnarelli, Division of Biosciences, Brunel University, UK

Chapter 19: Lamins and oxygen stress damage in cell proliferation - Takeshi Shimi and Robert D. Goldman, Feinberg School of Medicine, Department of Cell and Molecular Biology, Northwestern University, USA

Section VI: The nuclear envelope link to cell migration and metastasis

Chapter 20: Nuclear mechanics in cancer - Celine Denais and Jan Lammerding, Department of Biomedical Engineering and Weill Institute for Cell and Molecular Biology, Cornell University, USA

Chapter 21: Nuclear envelope in nuclear positioning and cell migration - David Razafsky, Denis Wirtz and Didier Hodzic, Department of Opthalmology and Visual Sciences, Washington University School of Medicine, USA

Chapter 22: Nesprins in cell stability and migration - Sascha Neumann and Angelika A. Noegel, Institute for Biochemistry, University of Cologne, Germany

Chapter 23: Connecting the nucleus to the cytoskeleton for nuclear positioning and cell migration - Daniel S. Osorio and Edgar R. Gomes, University Pierre et Marie Curie Paris, Faculty of Medicine, University of Porto, Groupe Hospitalier Pitie-Salpetriere, Institute de Myologie, France

Section VII: Towards a molecular explanation of prognostic links to the nuclear envelope.

Chapter 24: Nuclear envelope invaginations and cancer - Ashraf N. Malhas and David J. Vaux, Sir William Dunn School of Pathology, Oxford University, UK.

Chapter 25: Mechanisms of nuclear size regulation in model systems and cancer - Predrag Jevtic and Daniel L. Levy, Department of Molecular Biology, University of Wyoming, USA.

Chapter 26: Control of nuclear size by NPC proteins - Masatoshi Takagi and Naoko Imamoto, Celular Dynamics Laboratory, RIKEN, JAPAN.

Chapter 27: Do lamins influence disease progression in cancer? - Christopher J. Hutchison, School of Biological and Biomedical Sciences, Durham University, UK.


Titel: Cancer Biology and the Nuclear Envelope
Untertitel: Recent Advances May Elucidate Past Paradoxes
EAN: 9781489980311
ISBN: 978-1-4899-8031-1
Format: Fester Einband
Genre: Medizin
Anzahl Seiten: 611
Gewicht: g
Größe: H29mm x B244mm x T162mm
Jahr: 2014
Auflage: 2014



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