Calcium Metabolism, Bone and Metabolic Bone Diseases

The X. European Symposium on Calcified Tissues took place in Hamburg from 16th to 21 st September 1973. The financial backing came from the Gesund heitsbehorde der Freien und Hansestadt Hamburg (President Dr. Zylmann), the Bundesministerium fur Jugend, Familie und Gesundheit, and from industry. This made it possible to carry out the scientific program, to invite several European and non-European scientists, and to organize a social program designed to establish personal contact between delegates and to make visitors acquainted with our country. In the name of the organizing committee, we herewith express our warmest appreciation of all the help given to us. Professor Bartelheimer, as the representative of the Medical Faculty and on behalf of the President of the University of Hamburg, welcomed the Parti cipants in the symposium to our city. The history of these meetings began in Oxford in 1963, with the First European Bone and Tooth Symposium, organized by H. J. J. Blackwood, B. E. C. Nordin, and Dame Janet Vaughan. The idea was to found in Europe an institution simi lar to the American Gordon Research Conferences of Bone and Tooth. After the U. K. , the host countries were Belgium, Switzerland, the Netherlands, France, Sweden, Italy, Israel and Austria. The second symposium in Liege already bore the present name.

Inhalt
I. Methods for Analyzing Bone Metabolism Progress and Critical Remarks.- Morphological and Crystallographic Analysis of Bone Mineral.- Quantitative Aspects of Calcium Metabolism and Homeostasis.- A Time-Varying Model for Calcium Metabolism Including Diurnal Variations.- Quality Control and Correlations of Clinical Methods for Studying Metabolic Bone Disease.- Morphometric Microdensity Studies of Hard Tissue Sections, Utilising Optical Density Contour Maps and Associated Area Coordinated Computerised Data.- On Calcium Metabolism during Immobilization.- Limitations in Bone-Mass Measurements with 241Am.- Intestinal Absorption and Retention of Calcium Measured by Whole-Body Counting.- II. Pharmacology and Metabolism of Vitamin D.- Studies on the Metabolism, Mode of Action and Pharmacology of Vitamin D and Related Analogs.- Vitamin D-Dependent Calcium Binding Protein of Rat Renal Cortex.- The Effect of Disodium Ethane-1-hydroxy-1, 1-Diphosphonate on the Metabolism of Vitamin D.- The Effect of Estrogen on Calcium Binding Protein Activity in Odentogenic Epithelium of the Rat.- Effect of Vitamin D on the Bone in Anticonvulsant Osteomalacia.- The Effect of Vitamin D3 on Lanthanum Absorption: Suggestive Evidence for a Shunt Path.- The Effects of Cyclic AMP, Hormones and Ions on the Conversion of 25-Hydroxycholecalciferol (25-HCC) to 1,25-Dihydroxycholecalciferol (1,25-DHCC) in Isolated Chick Kidney Tubules.- Extrarenal Metabolism of High Doses of 25-(OH)-D3: a New Active Metabolite.- III. Metabolism and Action of Fluoride.- Fluoride and its Relation to Bone and Tooth.- Absorption, Distribution in Body Fluids, and Bioavailability of Fluoride.- Bone Body Fluid Fluoride Balance.- Possible Systemic Effects Following the Ingestion of Low Doses of Fluoride.- Effects of Bone Fluoride on Bone Resorption and Metabolism.- Urine Fluoride Levels Following Ingestion of Fluoridated Domestic Salt over Three Years.- Fluoridation of Drinking Water and Bone Mineral Content, Analyzed by Monochromatic (125I) Radiation Absorptiometry.- Effects of Supply and Withdrawal of Fluoride on the Concentration of Fluoride and Glycosaminoglycans in Cortical Bone from Rabbits.- Histological Bone Changes after Long-Term Treatment with Sodium Fluoride.- Long-Term Experience with Fluoride and Fluoride Combination Treatment of Osteoporosis.- IV. Collagen Structure and Calcification.- Collagen Structure and Calcification.- Calcification of Collagenous Material in vitro as a Model System for Biological Calcification.- Further Investigations on the Function of the Osteonic Lamellae According to Collagen and Crystallite Orientation.- The Lability of Aldimine Crosslinks on Dissolution of Chicken Bone Collagen by Protein Denaturants.- Comparison of Ca, P and S Levels in Predentine and Tendon.- The Role of Lysyl Residue in Collagen Structure with Calcification and Aging.- Evidence for a Role of Lysozyme in Endochondral Calcification.- The Formation of Bone Mineral.- V. Biochemistry and Histochemistry of Bone Disease.- Biochemistry of Bone Diseases.- Tetracycline Staining of Bone in Normal and Pathological States.- Biochemical Determinations in Serum and Bone Homogenates from Patients with Femurhead Necroses.- A Clinical and Biochemical Survey of Osteogenesis Imperfecta with Evidence for a Generalised Collagen Defect.- Analysis of Tissue PO2 and PCO2 in Healing Bone.- VI. Therapeutical Aspects of Bone Diseases.- Effect of Various Therapies on Bone Loss in Women.- Effect of Calcitonin in Paget's Disease.- Biochemical and Radiological Observations in Patients with Osteitis Deformans Treated with Synthetic Human Calcitonin.- Influence of a Diphosphonate and 1,25-Dihydroxycholecalciferol on Calcium Metabolism.- Effect of Various Doses of Disodium Ethane-1 -Hydroxy-1,1 -Diphos- phonate (Sodium Etidronate, EHDP) on Suppression of the Biochemical and Histological Abnormalities in Paget's Disease of Bone.- Different Behavior of 45Ca and 89Sr in Chronic Uremia in the Rat.- The Effect of 1,25-Dihydroxycholecalciferol in Patients with Vitamin D Resistant States (Chronic Renal Failure, Familial Hypophosphatemia, Gluten Sensitive Enteropathy and Hypoparathyroidism).- Treatment of Renal Osteodystrophy Using Vitamin D or High Dialysate Calcium Concentration.- The Effects of Calcium Supplementation of the Diet on Bone Mass in Women.- VII. Parathyroid Hormone and Calcitonin.- Chemical and Biologic Studies of Parathyroid Hormone, Proparathyroid Hormone and Fragments of Parathyroid Hormone.- Parathyroid Hormone: Structure and Immunoheterogeneity.- Immuno-Reactive Parathyroid Hormone during EDTA Infusion in Chronic Renal Failure.- Preliminary Studies on the Effect of Calcium on the Enzymatic Degradation of Human Calcitonin in the Dog.- Factors Determining the Calcitonin Response in Man.- Separation of the Hypocalcemic and Hypophosphatemic Effects of Calcitonin.- VIII. Varia.- Influences of Endogenous Parathyroid Hormone upon Development and Treatment (Calcium, Calcitonin, Sodium Fluoride) of Experimental Bone Atrophy.- Quantitative Analysis of Bone Changes in Hypercalcitonism (C-Cell Carcinoma).- Intestinal Calcium Absorption 0-30 Years Post Gastrectomy; Study with a Double Isotope Ratio Technique.- The Morphology of the Intestinal Calcium Excretion by the Paneth Cell of Rat, Mouse and Man.- Frictional Ablation a Neglected Factor in the Mechanisms of Hard Tissue Destruction?.- Tumoral Calcinosis with Hyperphosphatemia.- Chronic Effects of Parathyroid Hormone Infused to Dogs at Near-Physiological Rates.- The Calcium Orthophosphate Solubilities as Represented by a Model in Three Dimensions.- Index of Authors.