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The Role of Complexin in Regulated Exocytosis

  • Kartonierter Einband
  • 132 Seiten
This work has studied the role of complexin in regulated exocytosis, a key mechanism underlies hormone and neurotransmitter releas... Weiterlesen
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Beschreibung

This work has studied the role of complexin in regulated exocytosis, a key mechanism underlies hormone and neurotransmitter release and understanding of which will help to design therapeutic interventions in a lot of neuronal diseases or endocrine diseases. The work here systematically dissects the vesicle stages leading up to exocytosis using a knockout-rescue strategy in a mammalian model system. The work shows that adrenal chromaffin cells from CPX II knockout mice exhibit a markedly diminished readily releasable vesicle pool, while showing no change in the kinetics of fusion pore dilation or morphological vesicle docking. Overexpression of wildtype CPX II ? but not of SNARE-binding-deficient mutants -- restores the size of the readily releasable pool in knockout cells, and in wildtype cells it markedly enlarges the readily releasable pool. These results suggest that CPXs prime vesicles for exocytosis and, therefore, are positive regulators of Ca2+-triggered exocytosis.

Autorentext

Dr. Haijiang Cai is currenly a postdoc fellow in California Institute of Technology, USA. He received his B.Sc. from the University of Science and Technology of China and his Ph.D. from the University of Southern California, USA. His research interests include synaptic transmission and neural circuits.

Produktinformationen

Titel: The Role of Complexin in Regulated Exocytosis
Untertitel: A Study Shows that the SNARE-binding Protein Complexin is a Positive Regulator of Vesicle Priming in Fast, Calcium-triggered Exocytosis
Autor:
EAN: 9783639014396
ISBN: 978-3-639-01439-6
Format: Kartonierter Einband
Genre: Biologie
Anzahl Seiten: 132
Gewicht: g
Größe: H220mm x B220mm
Jahr: 2013
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