Copper Bioavailability and Metabolism

Nutrition is truly a science of the 20th century. That physiological disabilities could be caused by a lack of exogenous substances which could be supplied by foods is a concept of relatively recent origins. It is not surprising, therefore, that, until the last few years, much of nutritional science research was tied to: 1) establishing a cause and effect relationship between a physiological problem and its cure/prevention by a chemical substance in food; 2) quantifying the amount of the substance (nutrient) needed to prevent deficiency symptoms; and 3) quantifying the amounts of nutrients found in various food substances. That a nutrient might be present in apparently adequate amounts in foods consumed by an individual but could not be fully utilized because of the concurrent consumption of anti-nutrients has been recognized as being an important problem as, for example, iodine-deficiency goiters resulting from consumption of gOitrigens. That less specific, less dramatic interactions among nutrients and among nutrients and other food components might enhance or inhibit the absorption of nutrients from the intestines or of the metabolism of nutrients within the body is an area of current concern.

Inhalt
Copper in Foods and Factors Affecting its Availability.- Food Sources of Dietary Copper.- Stable Isotope Studies of the Effect of Dietary Copper on Copper Absorption and Excretion.- Influence of Ascorbic Acid, Zinc, Iron, Sucrose and Fructose on Copper Status.- Copper Absorption as Affected by Supplemental Calcium, Magnesium, Manganese, Selenium and Potassium.- The Type of Dietary Carbohydrate Consumed During Pregnancy and Lactation Determines Copper Status of the Fetus and the Neonate Rat.- Factors Affecting Copper Absorption in Humans and Animals.- Inhibitors of Copper Bioutilization: Fiber, Lead, Phytate and Tannins.- Copper Absorption and Transport.- Copper Transport: Insights into a Ceruloplasmin-Based Delivery System.- The Biodistribution of Radiocopper-Labeled Compounds.- Metalloforms of Metallothionein Induced by Parenteral Copper: The Influence of Route of Administration.- Mechanism of Copper Transport and Delivery in Mammals: Review and Recent Findings.- Copper Metabolism and Physiological Effects.- Copper and Zinc Status in Moderate Alcohol Intake.- Effect of Estrogen on Serum and Tissue Levels of Copper and Zinc.- Effects of Exercise Training on Human Copper and Zinc Nutriture.- Serum Total Cholesterol and HDL-Cholesterol Levels as Associated with Copper and Zinc Intake in Physically Active And Sedentary Elderly Men and Women.- Modulation of Long Chain Fatty Acid Unsaturation by Dietary Copper.- Ischemic Heart Disease as Copper Deficiency.- Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis.- Exocrine Pancreatic Function of Rats Consuming a High-Fructose, Low-Copper Diet.- Bioavailable Copper Complexes Offer a Physiologic Approach to Treatment of Chronic Diseases.- Changes in Serum Copper and Zinc During Treatment with Anticancer Drugs Interfering withPyridoxal Phosphate.- Effect of Copper on Immune Function and Disease Resistance.- Effects of Inflammation on Copper Antioxidant Enzyme Levels.- Copper-67 Labeled Porphyrin Localization in Inflamed Tissues.- Serum Copper Concentration as an Index of Clinical Lung Injury.- Serum Copper Concentration as an Index of Experimental Lung Injury.