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Bisphosphonates and Tumor Osteolysis

  • Kartonierter Einband
  • 92 Seiten
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Skeletal involvement is a frequent and troublesome complication affecting many patients with neoplastic disease, especially multip... Weiterlesen
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Skeletal involvement is a frequent and troublesome complication affecting many patients with neoplastic disease, especially multiple myeloma and cancer of the breast, lung, and prostate. This involve ment can finally lead to local bone destruction with resulting frac tures, local bone neoformation, or hypercalcemia. The latter com plicates the clinical course of 10%-20% of the patients with non-smaIl-cell lung cancer and mammary tumors. Both knowledge of the pathophysiologic mechanisms and treatment of this skeletal involvement have progressed substantially in the last years. One of the very recent therapeutic advances has been the finding that bis phosphonates, a family of compounds characterized by a P-C-P bond, are effective in alleviating some of these conditions. This volume represents the proceedings of a workshop held on December 4, 1987, in Lucerne, Switzerland, devoted to the use of bisphosphonates in tumoral bone disease. This educational work shop was organized by the Swiss Group for Clinical Cancer Research (SAKK) to foster international scientific exchange and to clarify experimental and clinical problems in the therapeutic appli cation of bisphosphonates. Experts from various countries were invited to present and discuss their experimental findings and their preliminary clinical results. This volume summarizes the invited contributions, which will be of major interest to clinical oncolo gists, surgeons, internists, endocrinologists, and pathologists con fronted with bone destruction in neoplastic disease. We acknowl edge gratefully the support of Boehringer Mannheim (Schweiz) AG, Rotkreuz.


This volume informs the reader about basic chemical and experimental aspects of the bisphosphonates, their application in neoplastic hypercalcemia, and the basic effects of these drugs in neoplastic osteolysis. Initial reports, which need confirmation by larger randomized studies, also deal with the long-term application and possibly favorable influence of bisphosphonates in metastatic bone disease. It is vital for medical oncologists and interested internists to keep abreast of recent information in this new area of clinical cancer research.


Contents: Bisphosphonates: A New Class of Drugs in Diseases of Bone and Calcium Metabolism.- Pathophysiological Aspects and Therapeutic Approaches of Tumoral Osteolysis and Hypercalcemia.- Use of Clodronate and Calcitonin in Hypercalcemia Due to Malignancy.- Treatment of Tumor Hypercalcemia with Clodronate.- Treatment of Tumor-Induced Osteolysis by APD.- Clodronate Therapy of Metastatic Bone Disease in Patients with Prostatic Carcinoma.- Effect of Long-Term Bisphosphonate Treatment on Morbidity Due to Bone Metastases in Breast Cancer Patients.- Subject Index.


Titel: Bisphosphonates and Tumor Osteolysis
EAN: 9783642836701
ISBN: 3642836704
Format: Kartonierter Einband
Herausgeber: Springer Berlin Heidelberg
Genre: Medizin
Anzahl Seiten: 92
Gewicht: 176g
Größe: H244mm x B170mm x T5mm
Jahr: 2011
Auflage: Softcover reprint of the original 1st ed. 1989

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