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Not only is the quantity of life science data expanding, but new types of biological data continue to be introduced as a result of... Weiterlesen
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Not only is the quantity of life science data expanding, but new types of biological data continue to be introduced as a result of technological development and a growing understanding of biological systems. Methods for analyzing these data are an increasingly important component of modern biological research. In Bioinformatics, leading researchers in the field provide a selection of the most useful and widely applicable methods, able to be applied as is, or with minor variations, to many specific problems. Volume I: Data, Sequence Analysis and Evolution examines a selection of methods involving the generation and organization of data, including sequence data, RNA and protein structures, microarray expression data and functional annotations, methods for discovering the functional components of genomes, whether they be genes, alternative splice sites, non-coding RNAs or regulatory motifs, and several of the most interesting methods in phylogenetics and evolution.

Encompasses topics from across the diverse field of bioinformatics through its broad scope approach

Over 80 authors from around the globe contribute to the two volumes, including many leading experts in their respective subjects

An inter-disciplinary collaboration involving biologists, biochemists, physicists, mathematicians, statisticians and computer scientists

Contains simplified descriptions, requiring a minimum of background knowledge, amenable to students and beginners in bioinformatics

References a wide variety of software tools and scripts, available online

Table of Contents Bioinformatics: Volume I: Data, Sequence Analysis and Evolution Section I: Data and Databases Chapter 1. Managing Sequence Data Ilene Karsch Mizrachi Chapter 2. RNA Structure Determination by NMR Lincoln G. Scott and Mirko Hennig Chapter 3. Protein Structure Determination by X-ray Crystallography Andrea Ilari and Carmelinda Savino Chapter 4. Pre-processing of Microarray Data and Analysis of Differential Expression Steffen Durinck Chapter 5. Developing an Ontology Midori A. Harris Chapter 6. Genome Annotation Hideya Kawaji and Yoshihide Hayashizaki Section II: Sequence Analysis Chapter 7. Multiple Sequence Alignment Walter Pirovano and Jaap Heringa Chapter 8. Finding Genes in Genome Sequence Alice Carolyn McHardy Chapter 9. Bioinformatics Detection of Alternative Splicing Namshin Kim and Christopher Lee Chapter 10. Reconsruction of full-length isoforms from Splice Graphs Yi Xing and Christopher Lee Chapter 11. Sequence Segmentation Jonathan Keith Chapter 12. Discovering Sequence Motifs Timothy L. Bailey Section III: Phylogenetics and Evolution Chapter 13. Modeling Sequence Evolution Pietro Lio and Martin Bishop Chapter 14. Inferring Trees Simon Whelan Chapter 15. Detecting the Presence and Location of Selection in Proteins Tim Massingham Chapter 16. Phylogenetic Model Evaluation Lars Sommer Jermiin, Vivek Jayaswal, Faisal Ababneh and John Robinson Chapter 17. Inferring Ancestral Gene Order Julian M. Catchen, John S. Conery and John H. Postlethwait Chapter 18. Genome Rearrangement by the Double Cut and Join Operation Richard Friedberg, Aaron E. Darling and Sophia Yancopoulos Chapter 19. Inferring Ancestral Protein Interaction Networks Jose M. Peregrin-Alvarez Chapter 20. Computational Tools for the Analysis of Rearrangements in Mammalian Genomes Guillaume Bourque and Glenn Tesler Chapter 21. Detecting Lateral Genetic Transfer: a Phylogenetic Approach Robert G. Beiko and Mark A. Ragan Chapter 22. Detecting Genetic Recombination Georg F. Weiller Chapter 23. Inferring patterns of migration Paul M.E. Bunje and Thierry Wirth Chapter 24. Fixed-Parameter Algorithms in Phylogenetics Jens Gramm, Arfst Nickelsen and Till Tantau


Titel: Bioinformatics
Untertitel: Volume I: Data, Sequence Analysis and Evolution
EAN: 9781588297075
ISBN: 1588297071
Format: Fester Einband
Herausgeber: Humana Press
Anzahl Seiten: 576
Gewicht: 1550g
Größe: H266mm x B198mm x T40mm
Jahr: 2008
Auflage: 2008

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