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I. MOLECULAR BIOLOGY OF TUMORS.
Brain Tumors
Introduction
Medulloblastoma
Glial Tumors
Introduction
The Significance of Immunohistochemistry
Original Immunohistochemical Observations
Intermediate filaments (IFs)
Expression of Homeobox B3, B4, and C6 Gene Products
Cell proliferation
Epidermal growth factor (EGF) and its receptor (EGFR)
p53, the guardian of the integrity of the genome
Apoptosis in Brain Tumors
Survivin
Tumor-related Neoangiogenesis in Childhood Brain Tumors
Presence of Matrix Metalloproteinases (MMPs)
The MAGE gene family
II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES
Experimental Therapies in Brain Tumors
Biologic Anti-Neoplastic Therapies
Introduction
Active nonspecific immunomodulation of natural immunity
Thymic hormones
Interferons: basic and preclinical studies
Tumor Necrosis Factors
The discovery of interleukin-2: basic principles
Administration of rIL-2 and LAK cells: preclinical trials
Angiogenesis Inhibition in Anti-Neoplastic Therapy
Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy
Active antigen specific immunotherapy (tumor vaccines)
Antigen Presentation within Childhood Brain Tumors
Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors
The Dendritic Cell Network
Antigen Presentation by DCs
The Significance of DCs in Anti-Neoplastic Immunotherapy
Introduction
Human Cancer Cell Related Antigens
Oncogenes and Growth Factors in Neoplastic Cells
Antibodies and Neoplastic Cells
Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry
Human Antibodies
Anti-Idiotypic Antibodies
Bispecific Antibodies
Radiolabeled Antibodies
Construction of Immunotoxins
Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells
Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity
Introduction
Cancer/Testis Antigens
Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance
Prologue
III. APPENDIX
Tissues and Tissue Handling
Libraries of Antibodies
Antigen Retrieval Technique
Immunoalkaline Phosphatase Antigen Detection Technique
Immunoperoxidase Antigen Detection Technique
Controls in Immunocytochemistry
Evaluation of the Immunoreactivity (immunostaining)
Tissue Processing for Tissue Culture Experiments
Preparation of Thymic, Peripheral Blood and Bone Marrow Cell Suspensions
Isolation of Cortical Thymocytes
Isolation of Thymic Nurse Cells (TNCs)
Thymic Stromal Cell (RE & DC) Cultures
Proliferation Assay (PA) for Thymocytes and Peripheral Blood Hematopoietic Cells
Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages
Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples
Zusammenfassung
I. MOLECULAR BIOLOGY OF TUMORS.
Brain Tumors
Introduction
Medulloblastoma
Glial Tumors
Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors
Introduction
The Significance of Immunohistochemistry
Original Immunohistochemical Observations
Intermediate filaments (IFs)
Expression of Homeobox B3, B4, and C6 Gene Products
Cell proliferation
Epidermal growth factor (EGF) and its receptor (EGFR)
p53, the guardian of the integrity of the genome
Apoptosis in Brain Tumors
Survivin
Tumor-related Neoangiogenesis in Childhood Brain Tumors
Presence of Matrix Metalloproteinases (MMPs)
The MAGE gene family
II. ANTI-NEOPLASTIC BIOLOGICAL THERAPIES
Experimental Therapies in Brain Tumors
Biologic Anti-Neoplastic Therapies
Introduction
Active nonspecific immunomodulation of natural immunity
Thymic hormones
Interferons: basic and preclinical studies
Tumor Necrosis Factors
The discovery of interleukin-2: basic principles
The lymphokine activated killer (LAK) cell phenomenon
Administration of rIL-2 and LAK cells: preclinical trials
Angiogenesis Inhibition in Anti-Neoplastic Therapy
Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy
Active antigen specific immunotherapy (tumor vaccines)
Antigen Presentation within Childhood Brain Tumors
Immunosuppression within the Cellular Microenvironment of Childhood Brain Tumors
The Dendritic Cell Network
Antigen Presentation by DCs
The Significance of DCs in Anti-Neoplastic Immunotherapy
Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeutic Agents to Cancer Cells
Introduction
Human Cancer Cell Related Antigens
Oncogenes and Growth Factors in Neoplastic Cells
Antibodies and Neoplastic Cells
Anti-neoplastic Immunotherapeutical Regiments Influenced by Immunohistochemistry
Human Antibodies
Anti-Idiotypic Antibodies
Bispecific Antibodies
Radiolabeled Antibodies
Construction of Immunotoxins
Monoclonal Antibodies: Carriers of Drugs, Toxins and Cytotoxic Cells
Clinical Trials with Monoclonal Antibodies and their Minimal Toxicity
Cancer-Testis Antigens: Promising Targets for Antigen Directed Anti-neoplastic Immunotherapy
Introduction
Cancer/Testis Antigens
Detection of Cancer/Testis Antigens in Various Malignant Neoplasms and their Therapeutic Significance
Prologue
III. APPENDIX
Materials and Methods
Tissues and Tissue Handling
Libraries of Antibodies
Antigen Retrieval Technique
Immunoalkaline Phosphatase Antigen Detection Technique
Immunoperoxidase Antigen Detection Technique
Controls in Immunocytochemistry
Evaluation of the Immunoreactivity (immunostaining)
Tissue Processing for Tissue Culture Experiments
Preparation of Thymic, Peripheral Blood and Bone Marrow Cell Suspensions
Isolation of Cortical Thymocytes
Isolation of Thymic Nurse Cells (TNCs)
Thymic Stromal Cell (RE & DC) Cultures
Proliferation Assay (PA) for Thymocytes and Peripheral Blood Hematopoietic Cells
Transmission Electronmicroscopy (TEM) of Cultured Thymic Medullary Cells (RE, DC, including LC, & IDC) and Macrophages
Scanning Electronmicroscopic (SEM) Procedure for Tissue Samples
Inhalt
Molecular Biology of Tumors.- Brain Tumors.- Immunophenotypic Characterization of Infiltrating Poly- and Mononuclear Cells in Childhood Brain Tumors.- Anti-Neoplastic Biological Therapies.- Experimental Therapies in Brain Tumors.- Biologic Anti-Neoplastic Therapies.- The Lymphokine Activeted Killer (LAK) Cell Phenomenon.- Angiogenesis Inhibition in Anti-Neoplastic Therapy.- Antigen Presentation by Dendritic Cells and Their Significance in Anti-Neoplastic Immunotherapy.- Genetically Engineered Antibodies for Direct Anti-Neoplastic Treatment and Systematic Delivery of Various Therapeu…