Angiogenesis in Health and Disease

Angiogenesis describes the formation of new blood vessels, which arise as outgrowths from existing vessels. In many physiological processes such as ovulation and wound healing angiogenesis is involved for a relatively short time. Otherwise under normal physiological conditions in the adult organism angiogenesis is an extremely slow process. By contrast in certain disease states such as diabetic retinopathy, arthritis, chronic inflammation, hemangiomas, etc., angiogenesis persists and contributes to the pathology of these disease states. Some 50 such "angiogenic diseases" have been described where angiogeneSiS is involved. Also in tumor growth and metastasis angiogenesis is an essential process and precedes neoplastic transformation. Hence, angiogenesis could become an important diagnostic tool and a target for developing therapeutic agents. This book contains the proceedings of the NATO Advanced Study Institute on "Angiogenesis in Health and Disease" held in Porto Hydra, Greece, from June 16-27, 1991. This meeting was a comprehensive review of endothelial cell biology and endothelial cell phenotypic and functional heterogeneity in relation to angiogenesis under physiological and pathological conditions. Numerous in vitro and in vivo models were presented, which are used to study angiogenesis at the molecular and cellular levels and to evaluate chemical compounds or naturally occuring substances for their effect on angiogenesis. The presentations and discussions at this meeting provided an opportunity for the basic science and the clinical disciplines to meet, exchange information and provide future research directions for many investigators engaged in the study of angiogenesis.

Klappentext

Proceedings of a NATO ASI held in Porto Hydra, Greece, June 16-27, 1991

Zusammenfassung
Proceedings of a NATO ASI held in Porto Hydra, Greece, June 16-27, 1991

Inhalt
Embryonic Development of Blood Vessels.- Regulation of Embryonic Blood Vessel Formation.- Role of Heterotypic Interactions between Endothelial Cells and Parenchymal Cells in Organospecific Differentiation: A Possible Trigger of Vasculogenesis.- Role of the Macrophage in the Regulation of Physiological and Pathological Angiogenesis.- Endothelial Cell Heterogeneity and Differentiation.- Heterogeneity in Endothelial Cells with Special Reference to their Growth Related Proteins.- Basic Fibroblast Growth Factor and Endothelial Cells: Receptor Interaction, Signal Transduction, Cellular Response - Dissociation of the Mitogenic Activity of bFGF from its Plasminogen Activator Inducing Capacity.- Role of Integrins in Endothelial Cell Function.- Specific Laminin Domains Mediate Endothelial Cell Adhesion, Alignment and Angiogenesis.- Production of Plasminogen Activators and Matrix Metalloproteinases by Endothelial Cells: Their Role in Fibrinolysis and Local Proteolysis.- Heparin Coordinately Suppresses Endothelial Cell Plasminogen Activator lnhibitor-1, Fibronectin and Thrombospondin mRNA Levels.- Properties of Endothelial Cells and Smooth Muscle Cells Grown in 3-Dimensional Collagen Lattices.- Effect of Ischaemia on Endothelial Cells.- Angiogenesis and Neoplastic Transformation.- Vascular Proliferation in Tumors and its Influence on Cancer Therapy.- The Development of the Tumor Vascular System: 2-D and 3-D Approaches to Network Formation in Human Xenografted Tumours.- Tumor Induced Angiogenesis: Effect of Platelet Derived Growth Factor (PDGF), Pentoxifylline, Sodium Diethyldithiocarbamate, Epsilon Amino Caproic Acid and Tranexamic Acid.- Vascular Growth in the Intermittently Ischemic Heart: AStudy on Growth Factors Expression.- Role of Mechanical Factors in Angiogenesis under Physiological and Pathophysiological Circumstances.- Low Molecular Mass Non-Protein Angiogenic Factors and their Role in the Disease Processes.- Calcification-Linked Angiogenesis and Bone Growth.- Involvement of Low Molecular Mass Angiogenic Factor (ESAF) in the Activation of Latent Matrix Metalloproteinases.- Hyaluronic Acid Promotes and Inhibits Angiogenesis.- Brain Tumor Angiogenesis: Drug Delivery and New Inhibitors.- Evaluation of Promoters and Inhibitors of Angiogenesis Using Basement Membrane Biosynthesis as an Index.- On Promoters of Angiogenesis and Therapeutic Potential.- The Development of Therapeutic Angiosuppression: Problems and Progress.- Anti-Angiogenic Versus Anti-Vascular Approaches to Cancer Therapy.- Assays for Angiogenic Factors.- Development and Validation of a Sponge Model for Quantitative Studies on Angiogenesis.- New Approaches to the Measurement of Proliferation Rates.- Factitious Angiogenesis: Endothelialization of Artificial Cardiovascular Prostheses.- Abstracts of Oral and Poster Presentations.- Participants.