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Amino Acid Derivatives

  • Fester Einband
  • 286 Seiten
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Beschreibung

Zusatztext ... the protocol-style makes the book a very valuable tool ... a source of knowledge and insipration for those who are just starting in the field ... a comprehensive supplement. Informationen zum Autor Dr Graham Campbell Barrett BSc (Lond) PhD (Lond) DPhil (Oxon) C Chem FRSC 10 Harberton Mead Oxford OX3 0DB Tel/fax: 01865 763322 Email GCBRCB@aol.com Klappentext Amino acids are increasingly becoming the first compound that chemists turn to when planning a synthesis leading to a homochiral target. Much of this activity is centered around peptide synthesis! however there is a very wide and demanding range of chemistry that describes the synthesis ofderivatives of the a-amino acids and some uses of those derivatives that do not involve peptides. This book supports several of these areas of chemistry and describes representative methods for introducing substituents at the amino group! modifying carboxy groups! and modifying the side-chains ofsome common a-amino acids. There is little discussion of peptide synthesis! although some of the basic protocols in the book are relevant to the modification of amino acids for this purpose. Instead! the authors here focus on the rapidly growing applications of amino acids in many other areas ofmodern organic synthesis. Any synthetic work carried out by those in the fields of organic and medicinal chemistry will be supported by the detailed practical protocols and background information provided in this book. Zusammenfassung This is a laboratory guide that covers the early stages of syntheses! which call for modifications to the functional groups of available L-amino acids. It offers guidance to the preparation of amino acid derivatives to be used in these broad area of synthesis as well as in amino acid analysis.

Autorentext

Dr Graham Campbell Barrett BSc (Lond) PhD (Lond) DPhil (Oxon) C Chem FRSC 10 Harberton Mead Oxford OX3 0DB Tel/fax: 01865 763322 Email GCBRCB@aol.com



Klappentext

Amino acids are increasingly becoming the first compound that chemists turn to when planning a synthesis leading to a homochiral target. Much of this activity is centered around peptide synthesis, however there is a very wide and demanding range of chemistry that describes the synthesis of
derivatives of the a-amino acids and some uses of those derivatives that do not involve peptides. This book supports several of these areas of chemistry and describes representative methods for introducing substituents at the amino group, modifying carboxy groups, and modifying the side-chains of
some common a-amino acids. There is little discussion of peptide synthesis, although some of the basic protocols in the book are relevant to the modification of amino acids for this purpose. Instead, the authors here focus on the rapidly growing applications of amino acids in many other areas of
modern organic synthesis. Any synthetic work carried out by those in the fields of organic and medicinal chemistry will be supported by the detailed practical protocols and background information provided in this book.



Zusammenfassung
This is a laboratory guide that covers the early stages of syntheses, which call for modifications to the functional groups of available L-amino acids. It offers guidance to the preparation of amino acid derivatives to be used in these broad area of synthesis as well as in amino acid analysis.

Inhalt

Preface; 1. Introduction; 2. Acylation and alkoxycarbonylation of the amino group; 3. Thioacylatin of the amino group of amino acids; 4. Mono- and Di-alkylatin of the amino group; 5. Reactions at the carboxy group of an amino acid: Amino acid salts; 6. Reactions at the carboxy group of an amino acid: Esterification of amino acids; 7. Carboxy group modifications; synthesis of a homochiral ketone derived from L-tryptophan; 8. Synthons derived from Aspartic and glutamic acids; 9. Benzophenone schiff bases of a-Amino acid esters as electrophiles. Addition of grignard reagents and alkly-lithiums to produce threo-amino alcohols and aminopolyols; 10. Synthetic uses of serine, threonine and cysteine; 11. Synthetic uses of methionine; 12. Metal-mediated modification of the side-chains of a-amino acids; 13. Diastereocontrolled functionalisation of enantiomerically pure 5-phenyl-1, 4-Oxazin-2-ones by azomethine ylid generation and trapping; 14. Reductive modifications of the carboxy-group; 15. Reactions at the a-Carbon Atom of a-Amino acid derivatives; 16. Modifications of the Aryl substitutents of a- and beta-aryl a-amino acids; 17. Isolation and chromatographic purification of reaction products from amino acids; Index

Produktinformationen

Titel: Amino Acid Derivatives
Editor:
EAN: 9780198558538
ISBN: 978-0-19-855853-8
Format: Fester Einband
Herausgeber: Oxford University Press
Genre: Naturwissenschaften allgemein
Anzahl Seiten: 286
Gewicht: 559g
Größe: H241mm x B159mm x T22mm
Jahr: 1999