Autorentext

Dr. Andrea Schlegel is an academic transplant staff surgeon at the Cleveland Clinic specialized in abdominal transplantation with her own research group. Her treatment philosophy is based on a patient-centric and shared-decision making while incorporating the most recent innovative technologies as she helps patients through their liver transplant journey. Her research interests include experimental and clinical research with a focus on machine perfusion to improve the safe utilization of organs. Dr. Schlegel is an international expert in the field with over 150 publications in high-impact journals on a broad range of topics including underlying mechanisms of machine perfusion and ischemia - reperfusion injury and the development of new biomarkers to predict organ viability. Dr. Schlegel is an associated Editor and Reviewer in over 20 leading journals in the field and delivers over 30 invited lectures per year worldwide.

Klappentext

Advancing Liver Transplantation: A Foundational Exploration of Machine Perfusion Techniques lays the groundwork for understanding the intricate world of liver transplantation within this groundbreaking reference book. Crafted with intuitive pedagogy and accessible formats, this reference serves as an entry point for students and entry-level practitioners, guiding them through fundamental concepts, processes, and applications in machine perfusion technology. From historical milestones to emerging innovations, the book provides a clear and comprehensive overview, ensuring readers quickly grasp essential knowledge to navigate this complex field. The meticulously structured table of contents acts as a roadmap, guiding readers through each section with ease. Starting with an introduction by editor Andrea Schlegel, the book explores historical perspectives and underlying mechanisms in Section 1, providing a solid foundation for further exploration. Contents dive into different machine perfusion techniques in Section 2, then navigate the practical aspects of implementation in clinical practice in Section 3. Finally, the book uncovers the latest innovations and emerging strategies in Section 4, consolidating understanding and building new connections along the way. Tailored for students, researchers, and practitioners across their career journey, this book caters to a diverse audience seeking to gain a solid foundation in liver transplantation and machine perfusion. Whether just starting an exploration or looking to refresh knowledge, this accessible and comprehensive coverage ensures the tools and insights needed to succeed in this dynamic field.

Inhalt

Section 1. Introduction in Historical perspectives and underlying mechanisms

1. History of liver preservation and machine perfusion

2. The role of machine perfusion in clinical practice: Why do we need it ?

   Section 2. Different Types of Machine perfusion techniques in liver transplantation

3. Overview of different liver preservation techniques
4. Mechanism of ischemia-reperfusion injury and protective effects of machine perfusion
5. Normothermic regional perfusion
6. Normothermic machine perfusion
7. Hypothermic machine perfusion
8. Current combinations of different perfusion techniques

9. The role of machine perfusion for liver viability assessment

   Section 3: Implementing machine perfusion in clinical practice

10. Establishing a clinical machine perfusion program
11. Impact of machine perfusion on healthcare economics

12. Balanced approach to the technological development of machine perfusion devices

    Section 4: Innovations and emerging strategies

13. Prolonged Liver Preservation
14. Biomedical engineering and liver modulation
15. Other emerging liver preservation techniques
16. Future perspectives of liver preservation