Viral Pathogenesis

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized.

The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome.

In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology.

• Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis
• Provides a fresh perspective on the approaches used to understand how viruses cause disease
• Features molecular profiling techniques, whole genome sequencing, and innovative computational methods
• Highlights the use of contemporary approaches and the insights they provide to the field

Inhalt

Viral Pathogenesis: From Basics to Systems Biology

1. The Human Toll of Viral Diseases: Past plagues and pending pandemics

Neal Nathanson

2. Historical Roots: The family tree of viral pathogenesis

William C. Summers

3. Basic Concepts: A step-by-step guide to viral infection

Robert Doms

4. Innate Immunity: Recognizing and responding to foreign invaders-no training needed

Christine A. Biron

5. Adaptive Immunity: Neutralizing, eliminating, and remembering for the next time

E. John Wherry, David Masopust

6. Aberrant Immunity: The consequences of overreacting or underperforming

E. John Wherry, David Masopust

7. Patterns of infection: Unwanted guests-quick visits and extended stays

Neal Nathanson and Francisco González-Scarano

8. Viral Oncogenesis: Infections That Can Lead to Cancer

Nicholas A. Wallace and Denise A. Galloway

9. HIV and AIDS: Science wrestles with 10,000 nucleotides-points but no pin

Guido Silvestri and Emily Cartwright

10. Animal Models: No model is perfect, but many are useful

Victoria K. Baxter and Diane E. Griffin

11. Systems Virology: Why Everybody Wants To Measure Everything

Marcus J. Korth and G. Lynn Law

12. The Virus-Host Interactome: Knowing the players to understand the game

Monika Schneider, Jeffery R. Johnson, Nevan J. Krogan, and Sumit K. Chanda

13. Host Genetics: It's not just the Virus, Stupid

Martin T. Ferris, Mark T. Heise, and Ralph S. Baric

14. Host metabolomics: Yet more ways your health is influenced by fat

Priscilla Yang

15. Mathematical Modeling: Solving equations to measure viral diseases - math rules

Alan S Perelson

16. Emerging viral diseases: Why we need to worry about bats, camels, and airplanes

James W. Le Duc and Neal Nathanson

17. Viral evolution: It's all about mutations

Adi Stern and Raul Andino

18. Viral Epidemiology: Tracking viruses with smartphones and social media

Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer and William J. Moss

19. Viral Vaccines: Fighting viruses with viruses

Juliet Morrison and Stanley Plotkin

20. Antiviral Therapy

Douglas D. Richman and Neal Nathanson

21. Breakthrough: Nobel prize discoveries in viral pathogenesis

Neal Nathanson

22. What lies ahead? Scientists look into their crystal balls