Veterinary Pharmacology and Therapeutics

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species.

• Provides current, detailed information on using drug therapies in all major domestic animal species

• Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine

• Includes extensive tables of pharmacokinetic data, products available, and dosage regimens

• Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology

• Includes access to a companion website with the figures from the book in PowerPoint

Autorentext

The editors

Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.

Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.

Zusammenfassung

Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species.

• Provides current, detailed information on using drug therapies in all major domestic animal species
• Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine
• Includes extensive tables of pharmacokinetic data, products available, and dosage regimens
• Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology
• Includes access to a companion website with the figures from the book in PowerPoint

Inhalt

Contributors xiii

Preface xix

About the Companion Website xxi

Section 1 Principles of Pharmacology 1

1 Veterinary Pharmacology: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich

2 Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere

3 Pharmacokinetics 41
Jim E. Riviere

4 Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain

5 Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez

Section 2 Drugs Acting on the Autonomic Nervous System 111

6 Introduction to the Autonomic Nervous System and Autonomic Pharmacology 113
Joshua A. Rowe, Rose M. McMurphy, Barbara J. Lutjemeier, and Michael J. Kenney

7 Adrenergic Receptor Agonists and Antagonists 131
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and ;Michael J. Kenney

8 Cholinergic Pharmacology: Autonomic Drugs 151
Rose M. McMurphy, Elizabeth G. Davis, Amy J. Rankin, Marjory A. Artzer, Barbara J. Lutjemeier, and Michael J. Kenney

Section 3 Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165

9 Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey

10 Neuromuscular Blocking Agents 194
Diane E .Mason and Christopher L. Norkus

11 Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey

12 Injectable Anesthetic Agents 247
Lysa P. Posner

13 Opioid Analgesic Drugs 281
Butch KuKanich and Mark G. Papich

14 Sedatives and Tranquilizers 324
Lysa P. Posner

15 Local Anesthetics 369
Thomas W. Vickroy

16 Euthanizing Agents 387
Anna Hampton

17 Anticonvulsant Drugs 395
Mark G. Papich

18 Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich

Section 4 Autacoids and Antiinflammatory Drugs 449

19 Histamine, Serotonin, and their Antagonists 451
Wolfgang Ba**umer

20 Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees

Section 5 Drugs Acting on the Cardiovascular System 501

21 Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames

22 Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere

Section 6 Drugs Affecting Renal Function and FluidElectrolyte Balance 553

23 Principles of AcidBase Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar

24 Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar

Section 7 Drugs Acting on Blood and Blood Elements 623

25 Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich

Section 8 Endocrine Pharmacology 647

26 Hypothalamic and Pituitary Hormones 649
Srujana Rayalam, Margarethe Hoenig, and Duncan C. Ferguson

27 Hormones Affecting Reproduction 674
Wolfgang Ba**umer, C. Scott Bailey, and John Gadsby

28 Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson 29 Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729<...