Beschreibung

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Inhalt
Imatinib Mesylate.- Erlotinib.- Axitinib (AG-013736).- Lapatinib.- Sorafenib.- Sunitinib.- Dasatinib.- Nilotinib.- Bosutinib.- Decitabine.- Azacytidine/Azacitidine.- Bortezomib.- Temsirolimus.- Danusertib.- Vismodegib.- Everolimus.- Vemurafenib.- Vandetanib.- Trametinib.- Dabrafenib.- Ponatinib.- Regorafenib.- Cabozantinib.- Revlimid.- Ibrutinib.- Qizartinib.- Ruxolitinib.- Carfilzomib.- Afitinib.

Produktinformationen

Titel:	Small Molecules in Oncology
Autor:	Uwe M. Martens
Editor:	Uwe M. Martens
EAN:	9783642544903
ISBN:	978-3-642-54490-3
Format:	E-Book (pdf)
Hersteller:	Springer Berlin Heidelberg
Herausgeber:	Springer
Genre:	Medizin
Veröffentlichung:	22.04.2014
Digitaler Kopierschutz:	Wasserzeichen
Dateigrösse:	5.94 MB
Anzahl Seiten:	417
Jahr:	2014
Untertitel:	Englisch
Auflage:	2nd ed. 2014