High Resolution NMR

High Resolution NMR: Theory and Chemical Applications, Second Edition covers the significant progress in understanding the NMR phenomena, instrumentation, and applications in chemical and biochemistry.

This edition is divided into 14 chapters and begins with the historical developments and theoretical aspects of NMR. Considerable chapters are devoted to the basic principles, chemical shifts, coupling constants, and analysis of complex spectra. Other chapters contain expanded topics on carbon-13, nuclear Overhauser effect, relaxation mechanisms, and the use of superconducting magnets. The remaining chapters examine the concepts of solvent effects, hydrogen bonding, and the use of NMR in quantitative analysis.

This book will prove useful to analytical chemists, biochemists, and researchers.

Inhalt

Preface to Second Edition
Preface to First Edition
Acknowledgments

1. Introduction
   1.1 Historical
   1.2 High Resolution NMR
2. The Theory of NMR
   2.1 Nuclear Spin and Magnetic Moment
   2.2 Classical Mechanical Description of NMR
   2.3 Quantum Mechanical Description of NMR
   2.4 Effect of the Boltzmann Distribution
   2.5 Spin-Lattice Relaxation
   2.6 Line Widths
   2.7 Saturation
   2.8 Macroscopic Magnetization
   2.9 The Bloch Equations: Nuclear Induction
   2.10 The Rotating Frame of Reference
   2.11 Adiabatic Passage; Ringing
   Problems
3. Instrumentation and Techniques
   3.1 Basic NMR Apparatus
   3.2 Requirements for High Resolution NMR
   3.3 Modulation and Phase Sensitive Detection
   3.4 Field/Frequency Control
   3.5 Signal/Noise and Size of Sample
   3.6 Fourier Transform Methods
   3.7 Intensity Measurements
   3.8 References
   3.9 Magnetic Susceptibility Measurements
   3.10 Frequency Calibration
   3.11 Control of Sample Temperature
   3.12 Useful Solvents
   3.13 Sampling Techniques
   3.14 Micro Techniques
   Problems
4. Chemical Shifts
   4.1 The Origin of Chemical Shifts
   4.2 Reference Compounds
   4.3 Chemical Shift Scales
   4.4 Magnetic Susceptibility Correction
   4.5 Empirical Correlations of Chemical Shifts
   4.6 Theory of Chemical Shifts
   4.7 Effect of Electron Density
   4.8 Magnetic Anisotropy and Chemical Shifts
   4.9 Ring Currents
   4.10 Nuclei Other Than Hydrogen
   4.11 Carbon-13
   4.12 Tabulations of Chemical Shifts and Spectra
   4.13 Empirical Estimation of Chemical Shifts
   4.14 Isotope Effects on Chemical Shifts
   4.15 Paramagnetic Species
   4.16 Lanthanide Shift Reagents
   Problems
5. Electron-Coupled Spin-Spin Interactions
   5.1 Origin of Spin-Spin Coupling
   5.2 Coupling between Groups of Equivalent Nuclei
   5.3 First-Order Analysis
   5.4 Signs of Coupling Constants
   5.5 Theory of Spin-Spin Coupling
   5.6 Some Observed Coupling Constants
   5.7 Correlation of Coupling Constants with Other Physical Properties
   5.8 Tabulations of Coupling Constants
   Problems
6. The Use of NMR in Structure Elucidation
   6.1 A Systematic Approach to the Interpretation of NMR Spectra
   6.2 Some Features of Carbon-13 Spectra
   6.3 Structure Elucidation of Polymers
   Problems
7. Analysis of Complex Spectra
   7.1 Notation
   7.2 Energy Levels and Transitions in an AX System
   7.3 Quantum Mechanical Formalism
   7.4 Nuclear Spin Basis Functions
   7.5 The Spin Hamiltonian
   7.6 The Two-Spin System without Coupling
   7.7 Factoring the Secular Equation
   7.8 Two Coupled Spins
   7.9 Selection Rules and Intensities
   7.10 The AB Spectrum
   7.11 Spectral Contributions from Equivalent Nuclei
   7.12 Symmetry of Wave Functions
   7.13 Summary of Rules for Calculating Spectra
   7.14 The Three-Spin System: ABC
   7.15 The A2B System
   7.16 The A3B System; Subspectral Analysis
   7.17 The ABX System
   7.18 Analysis of an ABX Spectrum
   7.19 Relative Signs of JAX and JBx in an ABX Spectrum
   7.20 ABX Patterns; Deceptively Simple Spectra
   7.21 "Virtual Coupling
   7.22 The AB'BB' and AA'XX' Systems
   7.23 Other Complex Spectra
   7.24 Aids in the Analysis of Complex Spectra
   7.25 Carbon-13 Satellites
   7.26 Effects of Molecular Asymmetry
   7.27 Polymer Configuration
   7.28 Use of Liquid Crystals as Solvents
   Problems
8. Relaxation
   8.1 Molecular Motions and Processes for Relaxation in Liquids
   8.2 Nuclear Magnetic Dipole Interactions
   8.3 Relaxation via Chemical Shift Anisotropy
   8.4 Spin-Rotation Relaxation
   8.5 Electric Quadrupole Relaxation
   8.6 Scalar Relaxation
   8.7 Relaxation by Paramagnetic Substances
   8.8 Some Chemical Applications
   8.9 Measurement of Relaxation Times
   Problems
9. Theory and Application of Double Resonance
   9.1 Notation and Terminology
   9.2 Experimental Techniques
   9.3 Theory of Double Resonance
   9.4 The Nuclear Overhauser Effect
   9.5 Structure Elucidation
   9.6 Location of "Hidden Lines
   9.7 Determination of Chemical Shifts
   9.8 Relative Signs of Coupling Constants
   9.9 Determination of Energy Level Arrangements
   9.10 "High Resolution Spectra in Solids
   Problems
10. Pulse Fourier Transform Methods
    10.1 RF Pulses and the Free Induction Decay
    10.2 Fourier Transformation of the FID
    10.3 Instrumental Requirements
    10.4 Data Processing in the Computer
    10.5 Sensitivity Enhancement by Time Averaging
    10.6 Measurement of Relaxation Times
    10.7 Two-Dimensional FT-NMR
    Problems
11. Exchange Processes: Dynamic NMR
    11.1 Spectra of Exchanging Systems
    11.2 Theory of Chemical Exchange
    11.3 Collapse of Spin Multiplets
    11.4 More Complete Theories of Exchange
    11.5 Double Resonance and Pulse Techniques
    11.6 CIDNP
    Problems
12. Solvent Effects and Hydrogen Bonding
    12.1 Medium Effects on Chemical Shifts
    12.2 Solvent Effects on Coupling Constants
    12.3 Solvent Effects on Relaxation and Exchange Rates
    12.4 Hydrogen Bonding
    Problems
13. Use of NMR in Quantitative Analysis
    13.1 Advantages of NMR in Quantitative Analysis
    13.2 Drawbacks and Problems in the Use of NMR in Quantitative Analysis
    13.3 Some Analytical Uses of NMR
14. Contemporary Developments in NMR
    14.1 Solids
    14.2 Multinuclear NMR
    14.3 Biochemical Studies
    14.4 NMR Imaging
    References
    Appendix A General NMR References
    Appendix B Nuclear Spins, Magnetic Moments, and Resonance Frequencies
    Appendix C Proton and Carbon-13 NMR Spectra of "Unknowns
    Appendix D Answers to Selected Problems
    Index