The Role of Glycosylation in Health and Disease

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans' functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Autorentext
Gordan Lauc is a Professor of Biochemistry and Molecular Biology at the University of Zagreb Faculty of Pharmacy and Biochemistry and founder and CEO of Genos Ltd. He was born in Osijek in 1970, graduated molecular biology at the University of Zagreb, Faculty of Science in 1992, and obtained PhD in Biochemistry and the University of Zagreb in 1995. He got his postdoctoral training at the Institute for Medical Physics and Biophysics in Münster and Johns Hopkins University in Baltimore. Since 1993 he is employed at the Faculty of Pharmacy and Biochemistry in Zagreb. Dr. Lauc is author of over 150 research papers published in international journals and six international patents. He was invited to lecture at numerous international conferences, elected for visiting professor at the Johns Hopkins University and in 2011 also inducted in the prestigious Johns Hopkins Society of Scholars. In 2012 he was appointed Honorary Professor at the University of Edinburgh and in 2015 also at Kings College London. He is a President of the International Glycoscience Organization, member of the Steering Committee of the European Glycoscience Forum, and Co-Director of the Human Glycome Project. Irena Trbojevic-Akmacic received her degree in Biochemistry and Analytical Chemistry at Faculty of Science, University of Zagreb in 2012 and her PhD degree in Biochemistry at the same University in 2015. Currently, she is working as a Head of UPLC Laboratory for Glycan Analysis in Genos Ltd, a private research organization that specializes in high-throughput glycomic analysis. Her research activities primarily focus on methods development for high-throughput N-glycan analysis and their application in population, genetic, epidemiologic and clinical glycomic studies. She has published 40 scientific papers in peer-reviewed international journals and participated in number of scientific trainings and conferences with oral and poster presentations.

Inhalt
Part I: Importance and functions of the human glycome1.N-glycosylation (Tetsuya Hirata, Yasuhiko Kizuka)2.Mucin type O-GalNAc glycosylation in health and disease (Ieva Bagdonaite, Emil M. H. Pallesen, Mathias I. Nielsen, Hans H. Wandall)3.Glycosphingolipids (Elena Chiricozzi, Massimo Aureli, Laura Mauri, Erika Di Biase, Giulia Lunghi, Maria Fazzari, Manuela Valsecchi, Emma Veronica Carsana, Nicoletta Loberto, Alessandro Prinetti, Sandro Sonnino)4.Glycosaminoglycans (Yuefan Song, Fuming Zhang, Robert J. Linhardt)5.Other types of glycosylation (Yohei Tsukamoto, Hideyuki Takeuchi)6.Extracellular vesicles and glycosylation (Yoichiro Harada, Yuki Ohkawa, Kento Maeda, Yasuhiko Kizuka, Naoyuki Taniguchi)7.Quantitative genetics of human protein N-glycosylation (Jasminka Kriti, Sodbo Zh. Sharapov, Yurii S. Aulchenko)8.Epigenetic regulation of glycosylation (Rossella Indellicato, Marco Trinchera)
Part II: Glycosylation in disease9.Glycosaminoglycans in neurodegenerative diseases (Weihua Jin, Fuming Zhang, Robert J. Linhardt)10.Glycosylation in autoimmune diseases (Marta Zbczyska, Pawe Link-Lenczowski, Ewa Poche)11.The role of glycosylation in infectious diseases (Xiao-Lian Zhang, Haoran Qu)12.The importance of glycosylation in COVID-19 infection (Tea Petrovic, Gordan Lauc, Irena Trbojevi-Akmai)13.The role of glycosylation in inflammatory diseases (Inês Alves, Manuel M. Vicente, Ana M. Dias, Joana Gaifem, Cláudia Rodrigues, Ana Campar, Salomé S. Pinho)14.Protein glycosylation in diabetes (Tamara tambuk, Olga Gornik)15.Glycosylation and cardiovascular diseases (Hesam Dashti, Maria Angelica Pabon Porras, Samia Mora)16.Glycosylation profiling as a biomarker of suboptimal health for chronic disease stratification (Xueqing Wang, Zhaohua Zhong, Lois Balmer, Wei Wang)17.Glycosylation and aging (Ana Cindri, Jasminka Kriti, Marina Martini Kavur, Marija Pezer)