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The Tumor Microenvironment

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The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include va... Weiterlesen
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The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed "immune surveillance" in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.

Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation.

PrefaceBruce Zetter, PhDTable of Contents:PHYSIOLOGICAL PARAMETERS1. Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer TherapyAnnamaria Rapisarda, PhD and Giovanni Melillo, MD 2. New Insights into Regulation of Tumor pH by Carbonic AnhydrasesPawel Swietach,DPhil, Adrian L. Harris, DPhil/MBChB, and Richard D. Vaughan-Jones1,PhD3. Hypoxia, Gene Expression and MetastasisOlga V. Razorenova, PhD and Amato J. Giaccia, PhD4. Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IXJaromir Pastorek, PhD and Silvia Pastorekova, PhD 5. Glycolytic Pathway as a Target for Tumor InhibitionWeiqin Lu, PhD and Peng Huang, MD/PhDCELLULAR COMPONENTSI. MALIGNANT CELLS6. Aberrant DNA Methylation in Cancer CellsToshikazu Ushijima, MD/PhD 7. DNA Repair and Redox SignalingMark R. Kelley, PhD, Millie M Georgiadis, PhD, and Melissa L. Fishel, PhD 8. Cancer Stem Cells and MicroenvironmentMario Federico, MD and Antonio Giordano, MD/PhD9. Epithelial-Mesenchymal Transition in Development and DiseasesYadi Wu,PhD and Binhua P. Zhou, MD/PhD10. Invasion and MetastasisDouglas M. Noonan, PhD, Giuseppina Pennesi, MD, and Adriana Albini, PhD11. Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the MicroenvironmentPaloma Bragado, PhD, Aparna C. Ranganathan, PhD, and Julio Aguirre-Ghiso, PhDII. VASCULATURE AND STROMA12. Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing ControversyRobert S. Kerbel1, PhD, Francesco Bertolini, MD/PhD, and Yuval Shaked, PhD 13. Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth Pravin J. Mishra, MS and Debabrata Banerjee, PhD 14. Integrin Signaling in Lymphangiogenesis Barbara Garmy-Susini, PhD 15. Role of Pericytes in Resistance to Anti-Angiogenic TherapyKoji Matsuo, MD, Chunhua Lu1, MD/PhD Mian M K. Shazad, MS/MD, Robert L. Coleman,MD, and Anil K. Sood, MD16. Tumour-Promoting Stromal Fibroblasts in Human CarcinomasUrszula M. Polanska, Msc/PhD, Kieran T. Mellody, BSc./MPhil., and Akira Orimo, MD/PhD*III. IMMUNE-MEDIATED CELLS17. Mast cells and tumor microenvironmentTheoharis C. Theoharides, MS/MD/PhD, Konstantinos-Dionysios Alysandratos, MD, Asimenia Angelidou, MD, and Bodi Zhang, MD/MPH 18. Macrophages in the Tumor MicroenvironmentMonica Escorcio-Correia, PhD and Thorsten Hagemann, MD/PhD 19. The Prognostic Significance of Tumor-Infiltrating LymphocytesPing Yu, MD/PhD and Yang-Xin Fu, MD/PhD20. The Pro-Inflammatory Milieu and Pre-Malignant Epithelial InitiationAdam Yagui-Beltran, MD, Lisa M. Coussens, PhD, Qizi Tang, PhD, and David Jablons, MD21. Natural Killer Cells for Adoptive ImmunotherapyJonathan E. Benjamin, MD/PhD and Sally Arai, MDEXTRACELLULAR MATRIX22. FibronectinAndreas Menrad, PhD23. Collagen in CancerJanelle L. Lauer, PhD and Gregg B. Fields, PhD24. Integrins and CancerLaurie G. Hudson,PhD and M. Sharon Stack, PhD25. Matrix Metalloproteinases and Cancer Cell Invasion/MetastasisStanley Zucker, MD and Jian Cao, PhD26. Tetraspanins and Cancer MetastasisMargot Zoller, PhDSECRETED PROTEINS27. Chemokines and MetastasisKalyan C. Nannuru, PhD, Seema Singh, PhD, and Rakesh K. Singh, PhD28. Transforming Growth Factor-? in Lung Cancer, Carcinogenesis and MetastasisSonia B. Jakowlew, PhD 29. Cooperative Interactions Between Integrins and Growth Factors in Pathological Angiogenesis Jennifer M. Roth, MS, Eric Tweedie, BS, and Peter C. Brooks, PhD30. The Extracellular Matrix and the Growth and Survival of TumorsYves DeClerck, MD 31. Secreted Growth Factors as Therapeutic TargetsBeverly A. Teicher, PhD 32. Adrenomedullin in Tumor Development Rebecca G. Bagley, MS


Titel: The Tumor Microenvironment
EAN: 9781441966155
ISBN: 978-1-4419-6615-5
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Hersteller: Springer New York
Herausgeber: Humana Press
Genre: Medizin
Anzahl Seiten: 770
Veröffentlichung: 02.09.2010
Jahr: 2010
Dateigrösse: 15.4 MB