Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated

Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism.

The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource:

• Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science

• Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers

• Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics

• Presents a new companion website with useful supplementary materials at www.asbmrprimer.com

Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Autorentext

John P. Bilezikian is the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University. He is Chief Emeritus of the Division of Endocrinology and Vice-chair of the Department of Medicine for International Research and Education. He is also Director Emeritus of the Metabolic Bone Diseases Program at Columbia University Medical Center.

Klappentext

THE AUTHORITATIVE REFERENCE TO BONE DISEASES AND DISORDERS OF MINERAL METABOLISM, REVISED AND UPDATED Now in its ninth edition, the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource:

• Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science
• Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers
• Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics
• Presents a new companion website with useful supplementary materials at www.wiley.com/go/asbmrprimer Written for advanced students, clinicians, and researchers, the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Inhalt
Contributors xi

Preface to the Ninth Edition of the Primer:
John P. Bilezikian xxiv

About ASBMR xxv

President's Preface Michael J. Econs xxvi

About the Companion Website xxvii

**Section I Molecular and Cellular Determinants of Bone Structure and Function 1
**Section Editor Karen Lyons

1 Early Skeletal Morphogenesis in Embryonic Development 3
Yingzi Yang

2 Endochondral Ossification 12
Courtney M. Karner and Matthew J. Hilton

3 Local and Circulating Osteoprogenitor Cells and Lineages 20
Naomi Dirckx and Christa Maes

4 Osteoblasts Function, Development, and Regulation 31
Elizabeth W. Bradley, Jennifer J. Westendorf, Andre J. van Wijnen, and Amel Dudakovic

5 Osteocytes 38
Lynda F. Bonewald

6 Osteoclast Biology and Bone Resorption 46
Hiroshi Takayanagi

7 Signal Transduction Cascades Controlling Osteoblast Differentiation 54
David J.J. de Gorter, Gonzalo SánchezDuffhues, and Peter ten Dijke

8 The TGF Superfamily in Bone Formation and Maintenance 60
Ce Shi and Yuji Mishina

9 Recent Developments in Understanding the Role of Wnt Signaling in Skeletal Development and Disease 68
Zhendong A. Zhong, Nicole J. Ethen, and Bart O. Williams

10 Mechanotransduction in Bone Formation and Maintenance 75
Whitney A. Bullock, Lilian I. Plotkin, Alexander G. Robling, and Fredrick M. Pavalko

11 The Composition of Bone 84
Adele L. Boskey and Pamela G. Robey

12 Assessment of Bone Mass, Structure, and Quality in Rodents 93
Jeffry S. Nyman and Deepak Vashishth

13 Skeletal Healing Cellular and Molecular Determinants 101
Alayna E. Loiselle and Michael J. Zuscik

14 Biomechanics of Fracture Healing 108
Elise F. Morgan, Amira I. Hussein, and Thomas A. Einhorn

**Section II Skeletal Physiology 115
**Section Editor Ego Seeman

15 Human Fetal and Neonatal Bone Development 117
Tao Yang, Monica Grover, Kyu Sang Joeng, and Brendan Lee

16 Skeletal Growth a Major Determinant of Bone's Structural Diversity in Women and Men 123
Ego Seeman

17 Racial Differences in the Acquisition and Agerelated Loss of Bone Strength 131
Shane A. Norris, Marcella D. Walker, Kate Ward, Lisa K. Micklesfield, and John M. Pettifor

18 Calcium, Vitamin D, and Other Nutrients During Growth 135
Tania Winzenberg and Graeme Jones

19 Mechanical Loading and the Developing Skeleton 141
Mark R. Forwood

20 Pregnancy and Lactation 147
Christopher S. Kovacs and Henry M. Kronenberg

21 Menopause and Agerelated Bone Loss 155
Carlos M. Isales and Ego Seeman

**Section III Mineral Homeostasis 163
**Section Editors David Goltzman and Harald Jüppner

22 Regulation of Calcium Homeostasis 165
Line Vautour and David Goltzman

23 Magnesium Homeostasis 173
Aliya Aziz Khan, Asiya Sbayi, and Karl Peter Schlingmann

24 Fetal Calcium Metabolism 179
Christopher S. Kovacs

25 FGF23 and the Regulation of Phosphorus Metabolism 187
Kenneth E. White and Michael J. Econs

26 Gonadal Steroids 194
Stavros C. Manolagas and Maria Schuller Almeida

27 Parathyroid Hormone 205
Thomas J. Gardella, Robert A. Nissenson, and Harald Jüppner

28 Parathyroid HormoneRelated Protein 212
John J. Wysolmerski and T. John Martin

29 CalciumSensing Receptor 221
Geoffrey N. Hendy 30 Vitamin D Production, Metabolism, Action, and Clinical Requirements 230
Daniel D. Bikle, John S. Adams, and Sylvia Christakos&l...