Preclinical Hyperthermia

Physicians and biologists here present their experimental work in the field of hyperthermia, paying particular regard to its relevance in clinical situations. Principles of heat action and combined treatment modalities are explicated. The main topics discussed are the effects of such treatment on normal tissues, animal tumors, malignant cell lines and human tumors.

Inhalt

Modification of Heat Action and Thermal Enhancement of Radio- and Chemotherapy.- Hyperthermic Toxicity and the Modulation of Heat Damage to Cell Protein Synthesis in HeLa Cells.- Membranes as Targets for Hyperthermic Cell Killing.- Sulfhydryl Compounds as Thermosensitizers.- Therapeutic Benefit from Combined Heat and Radiation.- Correlation Between Polymerase ? Activity and Thermal Radiosensitization in Chinese Hamster Ovary Cells.- Effect of Heat and Combined Treatments on Normal Tissues.- The Problem of Defining Thermal Dose.- Effect of Hyperthermia on Human Natural Killer Cells.- Effect of Hyperthermia at 40.5° C and Cytostatic Drugs on Human Bone Marrow Progenitor Cells.- Combined Heat and X-Ray Toxicities in Intestine and Skin.- Toxic Effects of Irradiation or Doxorubicin in Combination with Moderate Whole-Body Hyperthermia on Bone Marrow in Rats.- Cardiotoxicity of Moderate Whole-Body Hyperthermia, Doxorubicin, and Combined Treatment in Rats.- Predinical Hyperthermia in Animal Tumors and Malignant Cell Lines.- Effects of Hyperthermic Treatments on Malignant Cells and Animal Tumors: Introductory Remarks.- Hyperthermia and Microcirculatory Effects of Heat in Animal Tumors.- Importance of the Glutathione Level and the Activity of the Pentose Phosphate Pathway in Cellular Heat Sensitivity.- Potentiation of Hyperthermia by Lanthanum.- Interactions of Hyperthermia with Hypoxic Cell Sensitisers.- Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole.- Thermal Enhancement of Drug Cytotoxicity in Vivo and in Vitro.- Effect of Heat and Combined Treatments on Human Tumors.- Preclinical Hyperthermia in Human Tumors: Introductory Remarks.- Microcirculatory and pH Alterations in Isotransplanted Rat and Xenotransplanted Human Tumors Associated with Hyperthermia.- Effects of Heat Treatment in Vitro and in Vivo on Human Melanoma Xenografts.- Intrinsic Thermosensitivity of Various Human Tumors.- Importance of Thermotolerance for Radiothermotherapy as Assessed Using Two Human Melanoma Cell Lines.- In Vitro Thermochemotherapy in Ovarian Cancer.- Effect of Hyperthermia at 40.5° C and Chemotherapy on Various Human Tumors in Vitro.- Predictive Assays for Tumor Response to Single and Multiple Fractions of Hyperthermia.- Predicting the Sensitivity of Human Cancers to Combined Chemotherapy and Hyperthermia.