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A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.
Dr. Jayvadan Patel is a Professor of Pharmaceutics and Principal, Nootan Pharmacy College and Dean (Faculty of Pharmacy), Sankalchand Patel University, Visnagar, Gujarat, India. He has more than 25 years of academic and research experience, has published more than 230 research and review papers in international and national Journals. Dr. Patel is an author of 15 books and 65 book chapters. Dr. Patel has guided 45 PhD; 104 M Pharm students for dissertation work. Dr. Patel is recipient of several awards including, very prestigious AICTE-Visvesvaraya Best Teachers Award-2020 by All India Council for Technical Education, Government of India and APTI Young Pharmacy Teacher Award-2014 by Association of Pharmaceutical Teachers of India. He is serving as Peer reviewers of 58 well reputed journals. Dr. Patel is serving as an Associate editor/member editorial board of 15 journals.
Prof. Yashwant Pathak, M.S., Ph.D. in Pharmaceutical Technology from Nagpur University, India and EMBA and MS in Conflict Management from Sullivan University, KY, USA. He is the Associate Dean for Faculty Affairs at the College of Pharmacy, University of South Florida. Tampa, Florida. With extensive experience in academia as well as industry, he has to his credit more than 100 publications and 2 patents, including 5 books in Nanotechnology and 2 in Nutraceuticals and several books in cultural studies. He is also the Coordinator for the International Center for Cultural Studies, and is on the board of many organizations.
Part 1-Modelling of PK/PD for NPDDS.- Introduction to Nanoparticulate Drug Delivery Systems.- Nanoparticle Properties Affecting Pharmacokinetics of NPDDS.- Models Used for Biopharmaceutical Evaluation of NPDDS.- Models Used in the Pharmacokinetic Evaluation of NPDDS.- Models Used in the Pharmacodynamic Evaluation of NPDDS.- Preclinical Animal Models For Experimental Design of Pharmacokinetic Studies of NPDDS.- Pharmacokinetic Modelling Program (PKMP).- Part 2-PK/PD for Specific Nanocarriers.- Pharmacokinetic and Pharmacodynamics of Liposomal Nanoparticles.- Pharmacokinetics of Polymer Matrix Drugs (NPDDS).- Pharmacokinetics of Long-Circulating NPDDS.- Metallic Gold Nanoparticles in vivo Pharmacokinetics and X-ray Contrast imaging Studies.- Muco-adhesive NPDDS In Vitro and Pharmacokinetics Studies.- Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles.- Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles.- PKPD of PLGA-PEG-PLGA Triblock CoPolymeric Micelles.- Part 3-PKPD in Diseased Conditions for NPDDS.- Bridging Bio-Nanoscience and Cancer Nanomedicine.- Clearance Pathways and Tumor Targeting of Imaging Nanoparticles for Diagnostics.- PLGA Nanoparticles for Oral Delivery-Nephrotoxicity and Pharmacokinetic Studies.- Pharmacokinetics of Nanoparticle Systems for Pulmonary Delivery.- In vivo Biodistribution and Pharmacokinetic Studies of NPDDS for Brain Targeting.- Enhanced Bioavailability and Intestinal Uptake Nanoparticles After Oral Delivery.- Nanoparticle Pharmacokinetic Profiling In Vivo Using Magnetic Resonance Imaging.