Adenocarcinoma of the Esophagogastric Junction

Among malignant tumors, adenocarcinomas of the esophagogastric junction show the highest increase in incidence over the past three decades in Western industrialized countries. Accordingly, much effort is being devoted to basic and translational research in order to combat this frequently deadly disease.

This special volume, with contributions from experts in the field, covers all aspects of adenocarcinomas of the esophagogastric junction. Etiology, pathogenesis, classification, and clinical staging are discussed, and there is special emphasis on state of the art treatment techniques. The latter range from endoscopic mucosal resections or limited surgical resections for early cancers to multimodality treatment options for locally advanced tumors. Emerging quality issues in surgical management are also addressed. Detailed attention is paid to other important recent developments, including molecular response prediction in multimodality treatment and early metabolic response evaluation by PET and PET-CT during neoadjuvant treatment. The diagnosis of micrometastases and its potential impact on therapeutic strategies are explored, and the use of sentinel node technology is assessed. This volume will be of interest to all clinicians concerned with the diagnosis and management of this malignancy.

Inhalt
Epidemiology of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third.- Clinical Classification Systems of Adenocarcinoma of the Esophagogastric Junction.- Histopathologic Classification of Adenocarcinoma of the Esophagogastric Junction.- The Pathogenesis of Barrett's Metaplasia and the Progression to Esophageal Adenocarcinoma.- Differences in the Molecular Biology of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third.- Clinical Staging of Adenocarcinoma of the Esophagogastric Junction.- Endoscopic Mucosal Resection for Staging and Therapy of Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third.- Surgical Strategies for Adenocarcinoma of the Esophagogastric Junction.- Current Status of Sentinel Lymph Node Biopsy in Adenocarcinoma of the Distal Esophagus, Gastric Cardia, and Proximal Stomach.- Current Diagnosis and Future Impact of Micrometastases for Therapeutic Strategies in Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third.- Quality Indicators of Surgery for Adenocarcinoma of the Esophagus and Gastroesophageal Junction.- Peri-Operative and Complication Management for Adenocarcinoma of the Oesophagus and Oesophagigastric Junction.- Multimodality Therapy for Adenocarcinoma of the Esophagus, Gastric Cardia, and Upper Gastric Third.- Metabolic Response Evaluation by PET During Neoadjuvant Treatment for Adenocarcinoma of the Esophagus and Esophagogastric Junction.- Molecular Response Prediction in Multimodality Treatment for Adenocarcinoma of the Esophagus and Esophagogastric Junction.