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The foundational textbook on the study of virology
Basic Virology, 4th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.
This undergraduate-accessible book covers all the foundational topics in virology, including:
The basics of virology
Virological techniques
Molecular biology
Pathogenesis of human viral disease
The 4th edition includes new information on the SARS, MERS and COVID-19 coronaviruses, hepatitis C virus, influenza virus, as well as HIV and Ebola. New virological techniques including bioinformatics and advances in viral therapies for human disease are also explored in-depth. The book also includes entirely new sections on metapneumoviruses, dengue virus, and the chikungunya virus.
Autorentext
MARTINEZ J. HEWLETT is Professor Emeritus in the Department of Molecular and Cellular Biology at the University of Arizona.
DAVID CAMERINI is Assistant Professor in the Department of Molecular Biology and Biochemistry at the University of California Irvine.
DAVID C. BLOOM is Associate Professor in the Department of Molecular Genetics and Microbiology at University of Florida.
Klappentext
The foundational textbook on the study of virology
Basic Virology, 4th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.
This undergraduate-accessible book covers all the foundational topics in virology, including:
A full discussion of antiviral therapies, focusing particularly on combination therapies for HCV and HBV is also included. The sections on innate, intrinsic and adaptive immune responses to viral infections have also been updated.
Zusammenfassung
The foundational textbook on the study of virology
Basic Virology, 4th Edition cements this series' position as the leading introductory virology textbook in the world. It's easily read style, outstanding figures, and comprehensive coverage of fundamental topics in virology all account for its immense popularity.
This undergraduate-accessible book covers all the foundational topics in virology, including:
Inhalt
Preface
Preface to the Second Edition
Preface to the Third Edition
Preface to the Fourth Edition
Acknowledgements
[PN]PART I
[PT]VIROLOGY AND VIRAL DISEASE
[PTOC]INTRODUCTIONTHE IMPACT OF VIRUSES ON OUR VIEW OF LIFE
AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS
PATHOGENESIS OF VIRAL INFECTION
VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS
VIRUSES IN POPULATIONS
ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS
THE DYNAMICS OF VIRUS- HUMAN INTERACTIONS
PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS
ADDITIONAL READING FOR PART I
PROBLEMS FOR PART I
[CN]CHAPTER 1
[CT]INTRODUCTIONTHE IMPACT OF VIRUSES ON OUR VIEW OF LIFE
[CTOC] THE SCIENCE OF VIROLOGY
The effect of virus infections on the host organism and populationsviral pathogenesis, virulence, and epidemiology
The interaction between viruses and their hosts
The history of virology
Examples of the impact of viral disease on human history
Examples of the evolutionary impact of the virus-host interaction
The origin of viruses
Viruses have a constructive as well as destructive impact on society
Viruses are not the smallest self-replicating pathogens
QUESTIONS FOR CHAPTER 1
[CN]CHAPTER 2
[CT]AN OUTLINE OF VIRUS REPLICATION AND VIRAL PATHOGENESIS
[CTOC] VIRUS REPLICATION
Stages of virus replication in the cell
PATHOGENESIS OF VIRAL INFECTION
Stages of virus-induced pathology
Initial stages of infectionentry of the virus into the host
The incubation period and spread of virus through the host
Multiplication of virus to high levelsoccurrence of disease symptoms
The later stages of infectionthe immune response
The later stages of infectionvirus spread to the next individual
The later stages of infectionfate of the host
QUESTIONS FOR CHAPTER 2
[CN]CHAPTER 3
[CT]VIRUS DISEASE IN POPULATIONS AND INDIVIDUAL ANIMALS
[CTOC] THE NATURE OF VIRUS RESERVOIRSSome viruses with human reservoirs
Some viruses with vertebrate reservoirs
VIRUSES IN POPULATIONS
Viral epidemiology in small and large populations
Factors affecting the control of viral disease in populations
ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS
A mouse model for studying poxvirus infection and spread
Rabies: where is the virus during its long incubation period?
Herpes simplex virus latency
Murine models
Rabbit models
Guinea pig models
QUESTIONS FOR CHAPTER 3
[CN]CHAPTER 4
[CT]PATTERNS OF SOME VIRAL DISEASES OF HUMANS
[CTOC] THE DYNAMICS OF HUMAN-VIRUS INTERACTIONS
The stable association of viruses with their natural host places specific constraints on the nature of viral disease and mode of persistence
Classification of human disease-causing viruses according to virus-host dynamics
Viral diseases leading to persistence of the virus in the host are generally associated with viruses having long associations with human populations
Viral diseases associated with acute, severe infection are suggestive of zoonoses
PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS
Acute infections followed by virus clearing
Colds and respiratory infections
Influenza
Variola
Infection of an accidental target tissue leading to permanent damage despite efficient clearing
Persistent viral infections
Papilloma and polyomavirus infections
Herpesvirus infections and latency
Other complications arising from persistent infections
Viral and subviral diseases with long incubation periods
Rabies
HIVAIDS
Prion diseases
SOME VIRAL INFECTIONS TARGETING SPECIFIC ORGAN SYSTEMS
Viral infections of nerve tissue Examples of viral encephalit...