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Targeted Therapies in Cancer

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From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often... Weiterlesen
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Beschreibung

From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body's non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.



Inhalt
Prediction of Tumor Behaviour: Beyond typing and grading: target analysis in individualized therapy as a new challenge for tumour pathology. Oncogenic signaling pathways and deregulated target genes. Predictive pathology of cytostatic drug resistance and new anti-cancer targets. Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract. Resistance-associated signatures in breast cancer. Resistance to chemotherapy in ovarian carcinoma. Clinical, biological, and molecular aspects of metastasis in colorectal cancer. Prediction of efficacy and side effects of chemotherapy in colorectal cancer. Proteomic expression profiling of breast cancer.- Targeted Therapy and the Clinics: Targeted therapy and blood-brain-barrier. Cetuximab appraisal of a novel drug against colorectal cancer. C-kit, GIST and Imatinib. Antibody therapy in non-Hodgkin's lymphoma: the role of rituximab, 90Y-ibritumomab tiuxetan and alemtuzumab. Molecular and clinical aspects of proteasome inhibition in the treatment of cancer. Individualizied targeted therapy of malignant lymphomas: an outlook. Antiangiogenesis, anti-VEGF(R) and outlook. Morphological detection of hormone and growth factor receptors in breast cancer. What's in the Pipeline: Antigen specific cancer vaccines. Therapeutic vaccination for the treatment of malignant melanoma. Monoclonal and recombinant antibodies with T cell receptor-like reactivity. New molecular therapy targets in acute myeloic leukemia.

Produktinformationen

Titel: Targeted Therapies in Cancer
Autor:
Editor:
EAN: 9783540460916
ISBN: 978-3-540-46091-6
Format: E-Book (pdf)
Hersteller: Springer Berlin Heidelberg
Herausgeber: Springer
Genre: Medizin
Veröffentlichung: 10.06.2007
Digitaler Kopierschutz: Wasserzeichen
Dateigrösse: 5.45 MB
Anzahl Seiten: 262
Jahr: 2007

Weitere Bände aus der Buchreihe "Recent Results in Cancer Research"