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Hybrid Systems Biology

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This book constitutes the thoroughly refereed proceedings of the 6th International Workshop on Hybrid Systems Biology, HSB 2019, ... Weiterlesen
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Beschreibung

This book constitutes the thoroughly refereed proceedings of the 6th International Workshop on Hybrid Systems Biology, HSB 2019, held in Prague, Czech Republic, in April 2019. The 8 full papers presented in this book together with 1 short paper and 3 invited papers were carefully reviewed and selected from 13 submissions. They cover topics such as: modeling and analysis of metabolic, signaling, and genetic regulatory networks in living cells; models of tissues, organs, physiological models; models and methods coping with incomplete, uncertain and heterogeneous information including learning for biological systems, parametric synthesis and inference; stochastic and hybrid models in biology; hierarchical systems for multi-scale, multi-domain analysis; abstraction, approximation, discretization, and model reduction techniques; modeling, analysis and design for synthetic biology, cyber-biological systems and biomedical studies (e.g. therapies, teleoperation); game-theoretical frameworks and population models in biology (e.g. mixed-effects and Bayesian modeling); biological applications of quantitative and formal analysis techniques (e.g. reachability computation, model checking, abstract interpretation, bifurcation theory, stability and sensitivity analysis); efficient techniques for combined and heterogeneous (stochastic/deterministic, spatial/non-spatial) simulations for biological models; modeling languages and logics for biological systems with related analysis and simulation tools; and control architectures of biological systems including biology-in-the-loop systems and bio-robotics.



Inhalt

A multimodular system to study the impact of a focal lesion in neuronal cell cultures.- Reachability analysis and hybrid systems biology - In Memoriam Oded Maler.- Reaction networks, oscillatory motifs and parameter estimation in biochemical systems.- Fixed-point computation of equilibria in biochemical regulatory networks.- Rejection-based simulation of stochastic spreading processes on complex networks.- Controlling noisy expression through auto regulation of burst frequency and protein stability.- Extracting landscape features from single particle trajectories.- A hybrid HMM approach for the dynamics of DNA methylation.- Using a hybrid approach to model central carbon metabolism across the cell cycle.- Data-informed parameter synthesis for population Markov chains-. rPrism - A software for reactive weighted state transition models.- Hybrid modeling of metabolic-regulatory networks.

Produktinformationen

Titel: Hybrid Systems Biology
Untertitel: 6th International Workshop, HSB 2019, Prague, Czech Republic, April 6-7, 2019, Revised Selected Papers
Editor:
EAN: 9783030280420
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Hersteller: Springer International Publishing
Genre: Anwendungs-Software
Anzahl Seiten: 181
Veröffentlichung: 01.08.2019
Dateigrösse: 14.2 MB

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