Heat Shock Proteins of Malaria

This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.

Autorentext

Addmore Shonhai is a full Professor in Protein Biochemistry and head of the department of Biochemistry at the University of Venda, South Africa. His research focuses on understanding the role of heat shock proteins in parasite cyto-protection and virulence. He is particularly interested in studying the structure-function features of heat shock proteins that are responsible for their unique roles in various organisms despite their apparent sequence conservation. He is a recipient of a prestigious Georg Foster Research Fellowship awarded by the Alexander von Humboldt (AvH) of Germany and is a life-time member of the AvH fellowship program. His research has been primarily funded by the Germany Research Foundation (DFG) and National Research Foundation of South Africa. His passion is to train student scientists from disadvantaged background. In addition, he is interested in sharing his skills with collaborators from around the world but is especially interested in promoting science in Africa. To this end, he has conducted several workshops on protein biochemistry and molecular biology held at various institutions such as Babcock University, Obafemi Awolowo University, Nigeria Institute of Medical Research, and the University of Zimbabwe Medical School.

Didier Picard is a cellular and molecular biologist with almost 40 years of experience in basic research in academia. He obtained his PhD from the University of Zurich, Switzerland. Following a postdoc at the University of California in San Francisco, California, he became a full professor at the Department of Cell Biology at the University of Geneva, Switzerland. He has served as departmental chair and president of biology at the University of Geneva. His research interests include molecular chaperones (in vivo functions of Hsp90 and its cofactors) and steroid receptors (mechanisms of transcriptional activation of the estrogen receptor a, signaling crosstalk, antiestrogen resistance of breast cancer). He is the initiator and organizer of a twenty-year-old series of conferences dedicated to Hsp90, and most recently of a webinar series. He is a member of the European Molecular Biology Organization (EMBO), serves on the editorial boards of several scientific journals, and is currently president of the learned society "Life Sciences Switzerland".

Gregory L. Blatch has worked in academia for over 30 years, and his contributions to the academy and the promotion of science more broadly have been recognized through a number of awards (e.g. Senior Fellow of the Cell Stress Society International, FCSSI). He completed his PhD at the University of Cape Town and conducted postdoctoral research at Harvard University, before taking up academic teaching and research positions. He has a keen interest in the role of mentorship in the development of academic and research capability, and he has played a foundational leadership role at institutional, national and international levels in building academic and research entities. He is currently Emeritus Professor at The University of Notre Dame Australia, having most recently served as Pro Vice-Chancellor Research at Notre Dame. His personal research interests fall within the broad field of cellular stress biology, and he has been internationally recognized for his work on the role of stress in disease (e.g. cancer) and infection (e.g. malaria).

Inhalt
Emails and affiliation only provided for corresponding authors
Preface Acknowledgements

Contributors

About the Editors 1. The Importance of Molecular Chaperones in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparumJude Przyborski (jude.przyborski@ernaehrung.uni-giessen.de)University of Giessen, Germany (JP)
2. General Structural and Functional Features of Molecular ChaperonesAdrienne L. Edkins (a.edkins@ru.ac.za) and Aileen Boshoff (a.boshoff@ru.ac.za)Rhodes University, South Africa (ALE and AB)
3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium SpeciesAddmore Shonhai (Addmore.Shonhai@univen.ac.za)University of Venda, South Africa (AS)
4. Role of the Hsp40 Family of Proteins in the Survival and Pathogenesis of the Malaria ParasiteTanima Dutta, Eva-Rachele Pesce, Alexander G. Maier (alex.maier@anu.edu.au) and Gregory L. Blatch (g.blatch@ru.ac.za)Australian National University, Australia (AGM)Rhodes University, South Africa (GLB)
5. Role of Hsp90 in Plasmodium falciparum Malaria Dea Shahinas (dea.shahinas@alum.utoronto.ca) and Dylan R. Pillai (drpillai@ucalgary.ca)University of Toronto, Canada (DS)The University of Calgary, Canada (DRP)
6. The Role of Parasite Heat Shock Proteins in Protein Trafficking and Host Cell Remodeling Sarah C. Charnaud, Brendan S. Crabb and Paul R. Gilson (paul.gilson@burnet.edu.au)Burnet Institute, Australia (PRG)
7. Role of Heat Shock Proteins in Immune Modulation in MalariaTawanda Zininga (tzininga@sun.ac.za), Evelyn Böttger and Gabriele Multhoff (gabriele.multhoff@tum.de)Stellenbosch University, South Africa (TZ)Technische Universität München, Germany(GM)
8. Establishment of Plasmodium falciparum Extracellular Compartments in its Host ErythrocyteTawanda Zininga (tzininga@sun.ac.za), Alassane Mbengue, Laurence Berry and Catherine Braun-Breton (cbb@univ-montp2.fr)University of Montpellier, France (CB-B)
9. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Anti-Malarial Drug Discovery?**Chinedu P. Anokwuru (anokwuruchi@gmail.com), Stanley Makumire (stanmakster@gmail.com), Addmore Shonhai (addmore.shonhai@univen.ac.za)Tshwane University of Technology, South Africa (CPA)University of Cape Town, South Africa (SM)University of Venda, South Africa (AS)
10. Heat Shock Proteins as Targets for Novel Anti-Malarial Drug Discovery**Michael O. Daniyan (mdaniyan@oauife.edu.ng)Obafemi Awolowo University, Nigeria (MOD)
11. Heat Shock Proteins of Malaria: What Do We Not Know, and What Should the Future Focus Be? Addmore Shonhai (Addmore.shonhai@univen.ac.za) and Gregory L. Blatch (g.blatch@ru.ac.za)University of Venda, South Africa (AS)Rhodes University, South Africa (GLB)
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