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The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour.
Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., "systems biology" approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.
Autorentext
Valter Tucci graduated in Psychology in 2000, at the University of Padua, studying the cardiovascular changes associated with NREM and REM sleep states in humans. During his Ph.D studies he investigated the physiological and cognitive traits of narcoleptic patients. Then he moved to Boston where he studied sleep physiology and cognitive processes in rhesus monkeys and zebrafish. In 2003, he moved to Oxford (UK). At this time, he switched to work on behavioural neurogenetics. He was awarded a Career Development Fellowship by the MRC Mammalian Genetics Unit in Harwell and was then promoted to the post of Investigator Scientist two years later.
Valter Tucci is currently Team Leader of the Neurobehavioural Group at the Italian Institute of Technology (IIT). His research focuses on analysis of the effects that genetic and epigenetic mechanisms exert on sleep and cognition.
Zusammenfassung
The Handbook of Behavioral Genetics and Phenotyping represents an integrative approach to neurobehavioural genetics; worldwide experts in their field will review all chapters. Advanced overviews of neurobehavioural characteristics will add immense value to the investigation of animal mutants and provide unique information about the genetics and behavioural understanding of animal models, under both normal and pathological conditions. Cross-species comparisons of neurobehavioural phenotypes will pave the way for an evolutionary understanding of behaviour.
Moreover, while biological sciences are progressing towards a holistic approach to investigate the complexity of organisms (i.e., systems biology approach), an integrated analysis of behavioural phenotyping is still lacking. The Handbook of Behavioral Genetics and Phenotyping strengthens the cross-talk within disciplines that investigate the fundamental basis of behaviour and genetics. This will be the first volume in which traditionally distant fields including genomics, behaviour, electrophysiology, neuroeconomics, and computational neuroscience, among others, are evaluated together and simultaneously accounted for during discussions of future perspectives.
Inhalt
List of Contributors xix
Preface xxv
1 Genetic Screens in Neurodegeneration 1
Abraham Acevedo Arozena and Silvia Corrochano
Introduction 1
The Genetics of Neurodegenerative Disorders 2
Neurodegeneration Disease Models 4
Genetic Approaches to Discover New Genes Related to Neurodegeneration Using Disease Models 5
Saccharomyces cerevisiae 6
Caenorhabditis elegans 8
Drosophila melanogaster 9
Danio rerio 10
Mus musculus 11
Human Cellular Models and Post-mortem Material 14
The Future 14
Acknowledgments 15
References 15
2 Computational Epigenomics 19
Mattia Pelizzola
Background 19
Profiling and Analyzing the Methylation of Genomic DNA 19
Experimental Methods 20
Data Analysis 20
Array-based Methods 20
Sequencing-based Methods 20
Profiling and Analyzing Histone Marks 26
Experimental Methods 26
Data Analysis 27
Issues of Array-based Methods 27
Issues of NGS-based Methods 27
Integration with Other Omics Data 31
Chromatin States 32
Unraveling the Cross-talk Between Epigenetic Layers 33
References 33
3 Behavioral Phenotyping in Zebrafish: The First Models of Alcohol Induced Abnormalities 37
Robert Gerlai
Introduction 37
Alcohol Related Human Disorders: A Growing Unmet Medical Need 37
Unraveling Alcohol Related Mechanisms: The Importance of Animal Models 38
Face Validity: The First Step in Modeling a Human Disorder 39
Acute Effects of Alcohol in Zebrafish: A Range of Behavioral Responses 39
Chronic Alcohol Exposure Induced Behavioral Responses in Zebrafish 41
Effects of Embryonic Alcohol Exposure 42
Behavioral Phenotyping: Are We There Yet? 46
Assembling the Behavioral Test Battery 49
Concluding Remarks 50
References 50
4 How does Stress Affect Energy Balance? 53
Maria Razzoli, Cheryl Cero, and Alessandro Bartolomucci
Introduction 53
Stress 54
Energy Balance and Metabolic Disorders 55
Pro-adipogenic Stress Mediators 57
Pro-lipolytic Effect of Stress Mediators 57
How does Stress Affect Energy Balance? 57
Animal Models of Chronic Stress and their Impact on Energy Balance 58
Physical and Psychological (non-social) Chronic Stress Models 58
Mild Chronic Pain Models Mild Tail Pinch, Foot Shock 58
Thermal Models Cold and Heat Stress 64
Chronic Mild Stress Models: Chronic Mild Stress, Chronic Variable Stress, etc. 64
Restraint or Immobilization 65
Chronic Social Stress Models 66
Social Isolation, Individual Housing 66
Unstable Social Settings 66
Visible Burrow System 67
Intermittent Social Defeat (Resident/Intruder Procedure) 67
Chronic Psychosocial Stress, Sensory Contact, and Chronic Defeat stress 68
Stress, Recovery, and Maintenance: Insights on Adaptive and Maladaptive Effects of Stress 69
Molecular Mechanisms of Stress-Induced Negative and Positive Energy Balance 70
Serotonin (5-hydroxytryptamine, 5HT) 71
Orexin 71
Neuropeptide Y (NPY) 72
Ghrelin and Growth Hormone Secretagogue Receptor (GHSR) 72
Glucagon like Peptide 1 (GLP1) 73
Leptin 73
Amylin 74
Norepinephrine and 3-Adrenergic Receptor 74
Conclusion 74
References 75
5 Interactions of Experience-Dependent Plasticity and LTP in the Hippocampus During Associative Learning 91
Agnès Gruart, Noelia Madroñal, María Teresa Jurado-Parras, and José María Delgado-García
Introduction: Study of Learning and Memory Processes in Alert Behaving Mammals 91 Changes in Synaptic Strength During Lea...