Exploring Immunology

Knapp und präzise erklärt dieses einführende Lehrbuch der Immunologie die Funktion des Immunsystems anhand sorgfältig ausgewählter Beispiele aus der klinischen Praxis und dem Experiment. Von Büchern mit ähnlichem Themenspektrum unterscheidet es sich durch den klar evidenzbasierten Ansatz. Die Autoren -- ein erfahrener Dozent und ein angesehener Forscher -- regen dabei stets zur kritischen Reflexion des gelernten Stoffs an.
Website: www.wiley-vch.de/home/immunology

Autorentext
Gordon MacPherson is Reader in Experimental Pathology at the Sir William Dunn School of Pathology, University of Oxford and Tutor in Medicine, Oriel College Oxford. He has taught immunology to medical students for over 30 years in lectures, practical classes and tutorials at both introductory and Honours levels. He teaches all aspects of immunology, and in tutorials also covers microbiology and general pathology. His research interests are in immune regulation, particularly mucosal immunity, and the properties and roles of dendritic cells. He has published many papers (experimental and reviews) and has been an invited speaker at many international conferences

Jon Austyn is Professor of Immunobiology in the Nuffield Department of Surgery at the University of Oxford. He has taught extensively in all areas of fundamental immunology over many years, and designed the MSc course in Integrated Immunology at the University of Oxford, which he now co-directs. Jon Austyn has over 25 years research experience of dendritic cell immunobiology, particularly as applied to transplantation, infectious diseases and more recently cancer. He was recently awarded with distinction the Diploma in Learning and Teaching in Higher Education by the University of Oxford.

Zusammenfassung
This concise introductory textbook uses carefully chosen examples from clinical and experimental observations to provide an insight into the principles underlying the immune system. As a result, it encourages readers to ask critical questions in order to further advance our understanding of this unique organ. Both authors are experienced lecturers and highly regarded researchers.
The book is professionally illustrated in four color throughout with beautiful artwork which by itself distinguish the title from any comparable title.
Website: www.wiley-vch.de/home/immunology

Inhalt
INTRODUCTION Introduction

Immune Responses

Infection and Immunity

Immunopathology and Immunotherapy

Exploring Immunology

THE IMMUNE SYSTEM

Introduction

Host Defence Against Infection

Anatomical Basis of Immunity

Cellular Basis of Immunity

Molecular Basis of Immunity

Immune Responses and Disease

INFECTION AND IMMUNITY

Introduction

Pathogens and Infectious Disease

Host Defence Against Infection

Infection and Immunity in Action

Immunity and Vaccines

FUNCTIONAL ANATOMY OF THE IMMUNE SYSTEM

Introduction

Natural Barriers

Functional Anatomy of Innate Immunity

Functional Anatomy of Adaptive Immunity

Development of Blood Cells and Organs of Immunity

Stem Cell and Gene Therapy

INNATE IMMUNITY

Introduction

Induction of Innate Immunity

?Tissue-Resident Cells? of Innate Immunity

Recruited Effectors of Innate Immunity

Haematopoiesis and Myeloid Cells

Vaccines and Adjuvants

T CELL-MEDIATED IMMUNITY

Introduction

Major Histocompatibility Complex and Antigen Presentation

T Lymphocyte Activation

Effector and Memory Functions of T Cells in Infection

T Cell Development and Selection

Adoptive Cell Therapy

ANTIBODY-MEDIATED IMMUNITY

Introduction

Antibody Structure and Function

B Cell Responses

B Cell Memory, Antibodies and Long-Term Resistance to Re-Infection

Cell Differentiation and Selection

Therapeutic Antibodies

IMMUNITY, DISEASE AND THERAPY

Introduction

What are the Mechanisms of Tissue Damage Caused by the Immune System?

Why Do We Make Harmful Immune Responses to Harmless Antigens?

Immunopathology and Therapy in Action

Transplantation Immunology

Tumour Immunity

Conclusions

ANSWERS TO THE QUESTIONS

FURTHER STUDY QUESTIONS