Glucose-sensing Receptor in Pancreatic Beta-cells

Since the 1970s, there has been much discussion about the "glucoreceptor" and "substrate site" and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the "glucoreceptor theory."

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: "glucoreceptor theory".

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.

Autorentext

Itaru Kojima, M.D. Professor Emeritus

Institute for Molecular & Cellular Regulation, Gunma University

Klappentext

Since the 1970s, there has been much discussion about the glucoreceptor and substrate site and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the glucoreceptor theory.

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: glucoreceptor theory.

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.

Inhalt
.-1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR.-2Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells.-3KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR.-4Signaling System Activated by the Glucose-sensing Receptor

.-5The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells