Ferroptosis: Mechanism and Diseases

This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis.

While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.

Autorentext

Dr. Andrés F. Flórez is currently a Postdoctoral Fellow in the Department of Molecular and Cellular Biology (MCB) at Harvard University. His research is focused in understanding the oncogene-based mechanisms regulating ferroptosis and to use this knowledge for designing new therapeutic strategies. He is also interested in the role of ferroptosis in controlling bacterial cell populations.

Dr. Hamed Alborzinia is a Postdoctoral Fellow in the Division of Stem Cells and Cancer at the German Cancer Research Center (DKFZ). He also belongs to the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. His main research focus is to understand the metabolic properties of cancer cells in connection to novel forms of cell death, including ferroptosis.

Inhalt

Foreword. 4

Scott Dixon

1. Ferroptosis: Concepts and Definitions. 6

Andrés F. Flórez and Hamed Alborzinia

2. Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors. 13

Milica Vucetic, Boutaina Daher, Shamir Cassim, Scott Parks and Jacques Pouyssegur

3. Iron Homeostasis and Metabolism: Two Sides of a Coin. 37 Vivek Venkataramani
4. The Role of NCOA4-mediated Ferritinophagy in Ferroptosis. 58 Naiara Santana-Codina, Ajami Gikandi, Joseph D. Mancias
5. Emerging Role for Ferroptosis in Infectious Diseases. 80

Eduardo Pinheiro Amaral and Sivaranjani Namasivayam

6. Small Molecule Regulators of Ferroptosis. 108 Sylvain Debieu, Stéphanie Solier, Ludovic Colombeau, Antoine Versini, Fabien Sindikubwabo, Alison Forrester, Sebastian Müller, Tatiana Cañeque, Raphaël Rodriguez
7. Necroptosis, The other main Caspase-Independent Cell Death. 157 Larissa C. Zanetti and Ricardo Weinlich