Effects of Persistent and Bioactive Organic Pollutants on Human Health

Examines what we know about the relationship between organic
chemicals and human disease

Organic chemicals are everywhere: in the air we breathe, the
water we drink, and the food we eat. They are also found in a
myriad of common household and personal care products.
Unfortunately, exposure to some organic chemicals can result in
adverse health effects, from growth and developmental disorders to
cancer and neurodegenerative diseases. This book examines how
organic chemicals affect human health. It looks at the different
diseases as well as how individual organ systems are affected by
organic chemicals.

Effects of Persistent and Bioactive Organic Pollutants on
Human Health begins with an introductory chapter explaining why
we should care about organic chemicals and their effect on human
health. Next, the authors address such important topics as:

• Burden of cancer from organic chemicals

• Organic chemicals and obesity

• Effects of organic chemicals on the male reproductive
  system

• Organic chemicals and the immune system

• Intellectual developmental disability syndromes and organic
  chemicals

• Mental illness and exposure to organic chemicals

The book ends with an assessment of how much human disease is
caused by organic chemicals. Chapters have been contributed by
leading international experts in public and environmental health
and are based on the latest research findings. Readers will find
that all of the contributions are clear and easy to comprehend,
with extensive references for further investigation of individual
topics.

Effects of Persistent and Bioactive Organic Pollutants on
Human Health is recommended for students and professionals in
medicine as well as public and environmental health, bringing them
fully up to date with what we know about the relationship between
organic chemicals and human health.

Autorentext

DAVID O. CARPENTER, MD, is a public health physician. His research focuses on human diseases resulting from exposure to environmental contaminants. Following positions at the National Institute of Mental Health and the Armed Forces Radiobiology Research Institute, Dr. Carpenter joined the New York State Department of Health as Director of the Wadsworth Center for Laboratories and Research. He helped create and became the first Dean of the School of Public Health, a collaborative endeavor of the University at Albany (SUNY) and the New York State Department of Health. Upon stepping down as Dean, Dr. Carpenter founded the Institute for Health and the Environment. In 2011, the Institute was named a Collaborating Centre of the World Health Organization in Environmental Health.

Zusammenfassung

Examines what we know about the relationship between organic chemicals and human disease

Organic chemicals are everywhere: in the air we breathe, the water we drink, and the food we eat. They are also found in a myriad of common household and personal care products. Unfortunately, exposure to some organic chemicals can result in adverse health effects, from growth and developmental disorders to cancer and neurodegenerative diseases. This book examines how organic chemicals affect human health. It looks at the different diseases as well as how individual organ systems are affected by organic chemicals.

Effects of Persistent and Bioactive Organic Pollutants on Human Health begins with an introductory chapter explaining why we should care about organic chemicals and their effect on human health. Next, the authors address such important topics as:

• Burden of cancer from organic chemicals
• Organic chemicals and obesity
• Effects of organic chemicals on the male reproductive system
• Organic chemicals and the immune system
• Intellectual developmental disability syndromes and organic chemicals
• Mental illness and exposure to organic chemicals
  The book ends with an assessment of how much human disease is caused by organic chemicals. Chapters have been contributed by leading international experts in public and environmental health and are based on the latest research findings. Readers will find that all of the contributions are clear and easy to comprehend, with extensive references for further investigation of individual topics.

Effects of Persistent and Bioactive Organic Pollutants on Human Health is recommended for students and professionals in medicine as well as public and environmental health, bringing them fully up to date with what we know about the relationship between organic chemicals and human health.

Inhalt

Contributors vii

1. Introduction: Why Should We Care about Organic Chemicals
   and Human Health? 1

David O. Carpenter

2. Sources of Human Exposure 8

Martí Nadal and José L. Domingo

3. The Burden of Cancer from Organic Chemicals 26

Molly M. Jacobs, Rachel I. Massey, and Richard W. Clapp

4. Carcinogenicity and Mechanisms of Persistent Organic
   Pollutants 57

Gabriele Ludewig, Larry W. Robertson, and Howard P.
Glauert

5. Diabetes and the Metabolic Syndrome 101

Duk-Hee Lee and David R. Jacobs, Jr.

6. Mechanistic Basis for Elevation in Risk of Diabetes Caused
   by Persistent Organic Pollutants 130

Jérôme Ruzzin

7. Cardiovascular Disease and Hypertension 143

Marian Pavuk and Nina Dutton

8. Obesity 174

Eveline Dirinck, Adrian Covaci, Luc Van Gaal, and Stijn
Verhulst

9. Effects and Predicted Consequences of Persistent and
   Bioactive Organic Pollutants on Thyroid Function 203

Stefanie Giera and R. Thomas Zoeller

10. An Overview of the Effects of Organic Compounds on
    Women's Reproductive Health and Birth Outcomes 237

Susan R. Reutman and Juliana W. Meadows

11. Effects of Organic Chemicals on the Male Reproductive
    System 315

Lars Rylander and Anna Rignell-Hydbom

12. Effects of Endocrine-Disrupting Substances on Bone and
    Joint 332

Chi-Hsien Chen and Yueliang Leon Guo

13. Organic Chemicals and the Immune System 362

David O. Carpenter

14. Exposures to Organic Pollutants and Respiratory Illnesses
    in Adults and Children 384

Krassi Rumchev, Jeff Spickett, and Janelle Graham

15. Cognitive Function 400

Lizbeth López-Carrillo and Mariano E. Cebrián

16. Intellectual Developmental Disability Syndromes and
    Organic Chemicals 421

David O. Carpenter

17. Mechanisms of the Neurotoxic Actions of Organic Chemicals
    448

David O. Carpenter

18. Parkinson's Disease 471

Samuel M. Goldman

19. Psychiatric Effects of Organic Chemical Exposure
    514

James S. Brown, Jr.

20. Growth and Development 532

Lawrence M. Schell, Mia V. Gallo, and Kristopher K.
Burnitz

21. How Much Human Disease Is Caused by Exposure to Organic
    Chemicals? 557

David O. Carpenter

Index 570