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Cytoskeleton of the Nervous System

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This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more de... Weiterlesen
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Beschreibung

This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.

Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research. Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.

Autorentext
Ralph A. Nixon is the Director of Silberstein Institute and Center of Excellence on Brain Aging; a Professor of Psychiatry and Cell Biology at NYU Langone Medical Center; the Director of Research and The Center for Dementia Research at Nathan S. Kline Institute for Psychiatric Research.Aidong (David) Yuan is the Research Project Manager at the Center for Dementia Research, Nathan S. Kline Institute; a Research Assistant Professor of Psychiatry at New York University Langone Medical Center and New York University School of Medicine.

Klappentext
Without a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease.

Inhalt
Chapter 1: Central Axonal Development and Pathology in Early Life Robin L. Haynes, Hannah C. KinneyChapter 2: Microtubules in the nervous systemNobuyuki FukushimaChapter 3: Tau phosphorylationJesús Avila, Félix Hernández Chapter 4: Tau PathologyNicolas Sergeant, Luc BuéeChapter 5: Tauopathy and brain agingAkihiko TakashimaChapter 6: Microtubule-associated protein 4Kiyotaka Tokuraku, Kazuyuki Matsushima, Hiroyuki Nakagawa, Susumu KotaniChapter 7: Structure of Neural Intermediate FilamentsDavid A.D. ParryChapter 8: Alpha-internexin: the Fourth Subunit of Neurofilaments in the Mature CNSAidong Yuan, Ralph A. NixonChapter 9: Peripherin PathologyJesse R. McLean, Janice RobertsonChapter 10: Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament familyTakahiro GotowChapter 11: Neurofilament TransportAndrew J Grierson and Christopher C.J MillerChapter 12: Knockout models of neurofilament proteinsRodolphe Perrot, Jean-Pierre JulienChapter 13: Neurofilaments and Radial Growth: Deconstruction of a hypothesis through the construction of gene targeted miceMichael L. Garcia, Devin M. BarryChapter 14: Deregulation of Cytoskeletal Protein Phosphorylation and NeurodegenerationJyotshnabala Kanungo, Ya-li Zheng, Parvathi Rudrabhatla, Niranjana D. Amin, Bibhutibhushan Mishra, Harish C. PantChapter 15: Neurofilaments in Aged AnimalsShin-ichi Hisanaga, Takahiro Sasaki, Atsuko UchidaChapter 16: Neurofilament changes in Multiple SclerosisElizabeth Gray, Alastair WilkinsChapter 17: Intermediate filament interactions in neuronsKevin G. Young, Rashmi KotharyChapter 18: Tropomyosins in Neuronal Morphogenesis and DevelopmentNikki Margarita Curthoys, Peter William Gunning, Thomas FathChapter 19: The Driving Machinery for Growth Cone NavigationTakuro Tojima, Hiroyuki KamiguchiChapter 20: Glial Fibrillary Acidic Protein: The intermediate filament protein of astrocytesDouglas L. Eng, Lawrence F. EngChapter 21: Axonal Transport Mechanisms in Cytoskeleton Formation and RegulationAidong Yuan, Ralph A. NixonChapter 22: Axonal transport and motor neuron diseaseAnna-Lena Ström, Lawrence J. Hayward, Edward J. Kasarskis, Haining ZhuChapter 23: In vivo imaging of axonal transport in aging and Alzheimer's diseaseDonna J. Cross, Satoshi MinoshimaChapter 24: Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and DiseaseBen G. Szaroa, Michael J. StrongChapter 25: Crosstalks between myelinating cells and the axonal cytoskeletonRodolphe Perrot, Joël EyerChapter 26: Topographic regulation of neuronal intermediate filament proteins by phosphorylation: In health and diseaseParvathi Rudrabhatla, Harish C PantChapter 27: Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathyHsinlin T Cheng, Brian Callaghan, Jacqueline R Dauch and Eva L FeldmanChapter 28: Effects of Insulin on Tau and NeurofilamentR. Schechter, K.E. MillerChapter 29: Ethanol effects on the cytoskeleton of nerve tissue cellsSergio G. Evrard, Alicia Brusco

Produktinformationen

Titel: Cytoskeleton of the Nervous System
Editor:
EAN: 9781441967879
ISBN: 978-1-4419-6787-9
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Herausgeber: Springer
Genre: Medizin
Anzahl Seiten: 774
Veröffentlichung: 04.02.2011
Jahr: 2011
Untertitel: Englisch
Dateigrösse: 17.5 MB