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The Cutaneous Lymphoid Proliferations

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A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease.Clas... Weiterlesen
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Beschreibung

A masterful and thorough revision of the only single-source, authoritative reference on cutaneous lymphoproliferative disease.

Classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin
Covers a broad spectrum of topics ranging from the role of the immune system in the pathogenesis of cutaneous lymphocytic infiltrates to one describing the immunohistochemica nd molecular aspects of lymphoid neoplasia.
Each chapter contains an extensive array of 'clinical vignettes' clearly showing the application of principles and treatment techniques discussed in the chapter
Presents a succinct and logical approach to the diagnosis of most cutaneous lymphocytic infiltrates and discusses the interplay between the immune system in the propagation of lymphocytic infiltrates focusing on the role of iatrogenic and endogenous immune dysregulation. The molecular and cytogenetic basis of lymphoid neoplasia is considered in great detail.
Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 200 new images in the new edition

Cynthia M. Magro MD
Professor of Pathology and Laboratory Medicine
Department of Pathology, Cornell University
Weill Medical College
New York, USA

A. Neil Crowson MD
Professor of Pathology, Departments of Dermatology, Pathology, and Surgery
University of Oklahoma, and Regional Medical Laboratory
Tulsa, OK, USA

Martin C. Mihm Jr. MD
Professor of Pathology
Department of Pathology
Massachusetts General Hospital and Harvard Medical School
Boston, MA, USA


Autorentext

Cynthia M. Magro MD
Professor of Pathology and Laboratory Medicine
Department of Pathology, Cornell University
Weill Cornell Medicine
New York, NY, USA

A. Neil Crowson MD
Clinical Professor of Dermatology, Pathology, and Surgery
Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory
President of Pathology Laboratory Associates
Tulsa, OK, USA

Martin C. Mihm MD
Clinical Professor of Pathology and Dermatology, Harvard Medical School
Director of Melanoma Program, Dermatology, Brigham and Women's Hospital
Co-Director of Melanoma Program, Dana-Farber and Brigham and Women's Cancer Center
Director, Mihm Cutaneous Pathology Consultative Service
Brigham and Women's Hospital
Boston, MA, USA



Klappentext

The Cutaneous Lymphoid Proliferations is the go-to reference for a complete, authoritative treatment of the clinical features, phenotype, pathogenesis, histopathology, diagnosis, and treatment of lymphocytic infiltrates of the skin. This second edition incorporates the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry and brings readers up to date with the most current thinking in the field.

The book starts off with a clinical atlas and introduction to the ontogeny and biology of the lymphoid system. Next, the authors explore novel molecular approaches to the diagnosis of cutaneous lymphoid proliferation and benign lymphocytic infiltrates. The remaining chapters concentrate on major inflammatory skin diseases and lymphoproliferative disorders, including chronic lymphocytic leukemia, lupus, adult T cell leukemia, and primary cutaneous Hodgkin's disease.

The title:

- Discusses additional hematologic dyscrasias, including double hit B cell lymphoma, type D lymphomatoid papulosis, myxoid anaplastic large cell lymphoma, and myeloid dendritic cell leukemia

- Contains brand new content on paraneoplastic cutaneous manifestations of lymphoproliferative disease, and myelomonocytic dyscrasias, including terminally differentiated histiocytopathies such as Langerhans cell histiocytopathy including Langerhans cell sarcoma and indeterminate cell proliferative disorder

- Covers the role of the immune system in the pathogenesis of cutaneous disease

- Contains numerous new clinical vignettes that clearly show the application of principles and treatment techniques discussed in the chapter

- Discusses the relationships between therapeutic drugs and cutaneous eruptions and carefully notes important drug reactions

- Contains hundreds of full-color, high-quality clinical and histologic photographs, with over 100 new

A classic reference for unsurpassed coverage of lymphocytic infiltrates of the human skin.

Inhalt

Acknowledgments, viii

1 Introduction to the Classification of Lymphoma 1

Kiel LukesCollins, and Working Formulation classifications 1

WHO, REAL, EORTC, and the Combined WHO/EORTC classifications 2

Summary 7

References 8

Appendix: Definitions of key terms and techniques 9

2 The Therapy of Cutaneous T Cell Lymphoma 14
Benjamin H. Kaffenberger, Mark A. Bechtel, and Pierluigi Porcu

Introduction 14

Diagnostic work-up and staging procedures 14

CTCL therapies 15

Goals of therapy in advanced-stage CTCL 16

Extracorporeal photopheresis (ECP) 17

Interferons 17

Retinoids 17

Immunotoxins 18

Monoclonal antibodies 18

Histone deacetylase inhibitors (HDACi) 19

Antibody drug conjugates (ADC) 19

Cytotoxic chemotherapy 19

Investigational therapies 20

TLR agonists and cytokines 20

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) 20

References 21

3 Molecular Analysis in Cutaneous Lymphoid Proliferation 23
Shabnam Momtahen, Cynthia Magro, and Carl Morrison

Introduction 23

Immunoglobulin and T cell receptor structure 23

PCR design for determination of clonality 24

Detection of PCR products for clonality 24

Evaluation of results 25

The value and utility of molecular diagnostics in primary cutaneous lymphomas 26

Limitations of clonality assessment by PCR 27

Case vignettes 29

References 36

4 Benign Lymphocytic Infiltrates 37

Introduction 37

Spongiotic and eczematous dermatitis 37

Other spongiotic/eczematous tissue reactions 40

Other causes of subacute eczematous dermatitis 40

Interface dermatitis: cell-poor vacuolar interface dermatitis 42

Interface dermatitis: lichenoid pattern 46

Diffuse and nodular lymphocytic dermal infiltrates without atypia 51

Diffuse and nodular lymphocytic infiltrates associated with autoimmune disease 53

References 57

5 Reactive Lymphomatoid Tissue Reactions Mimicking Cutaneous T and B Cell Lymphoma 59

Lymphomatoid drug eruptions 59

Molecular profile of lymphomatoid drug eruptions 61

Pathogenetic basis of lymphomatoid drug reactions 62

Reactive lymphomatoid lesions encountered in lesions of collagen vascular disease 63

Angiomatous Variants of Pseudolymphoma 67

Case vignettes 69

References 86

6 Precursor Lesions of Cutaneous T Cell Lymphoma 89

Cutaneous T cell lymphoid dyscrasia 89

Large plaque parapsoriasis 90

Hypopigmented interface T cell dyscrasia: a unique indolent T cell dyscrasia 91

Pigmented purpuric dermatosis (PPD) 92

Pityriasis lichenoides 94

Idiopathic erythroderma (pre-Sézary) 96

Syringolymphoid hyperplasia with alopecia 96

Folliculotropic T cell lymphocytosis/pilotropic T cell dyscrasia 97

Idiopathic follicular mucinosis/alopecia mucinosa 98

Keratoderma-like T cell dyscrasia 99

Atypical lymphocytic lobular panniculitis 100

Case vignettes 102

References 132

7 Marginal Zone Lymphoma and Other Related Post Germinal Center B Cell Lymphoproliferative Disorders of The Skin 134

Marginal zone lymphoma 134

Blastic marginal zone lymphoma 140

Epidermotropic marginal zone lymphoma 140

Castleman disease 141

Primary cutaneous plasmacytoma 142

Case vignettes 145

References 166

8 Primary Cutaneous Follicle Center Cell Lymphoma 169

Clinical features 169

Pathology 169

Phenotypic profile 171

Molecular studies 172

Pathogenesis 172

Cytogenetics 172

Case vignettes 174

Additional molecular and cytogenetic study 185

References 186

9 Primary Cutaneous Diffuse Large B-Cell Lymphoma Including the Leg Type and Precursor B Cell Lymphoblastic Lymphoma 187

Primary cutaneous diffuse large B cell lymphoma 187

Systemic diffuse large B cell lymphomas with a propensity to involve the skin 197

Case vignettes 200

Additional light microscopic, phenotypic, molecular, cytogenetic studies 210

References 215

10 Intravascular Lymphoma 218

Clinical features 218

Light microscopic findings 219

Phenotypic profile 219

Molecular and cytogenetic studies 219

Pathogenesis 219

Differential diagnosis 219

Intravascular anaplastic large cell lymphoma 219

Benign intravascular proliferations of histiocytes and reactive T cells 220

Case vignettes 221

References 224

11 Cutaneous Mantle Cell Lymphoma 225

Clinical features 225

Light microscopic findings 225

Phenotypic profile 226

Molecular studies 227

Cytoge...

Produktinformationen

Titel: The Cutaneous Lymphoid Proliferations
Untertitel: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin
Autor:
EAN: 9781118776445
ISBN: 978-1-118-77644-5
Digitaler Kopierschutz: Adobe-DRM
Format: E-Book (epub)
Herausgeber: Wiley-Blackwell
Genre: Medizin
Anzahl Seiten: 568
Veröffentlichung: 17.12.2015
Jahr: 2015
Auflage: 2. Aufl.
Untertitel: Englisch
Dateigrösse: 176.5 MB