Cardiac Biomarkers

This book presents a comprehensive compendium of case studies to inform clinicians how to optimally deploy the major clinically utilized biomarkers in cardiology.

Biomarkers now play an integral role in the treatment and management of patients with congestive heart failure and acute ischemic heart disease because they provide crucial information about the status of individual patients. For that reason, it is important for clinicians to understand the basis for the use of these markers. Every reader may not have the laboratory and/or clinical expertise to understand all the details associated with the use of these markers, which is why this book takes a case oriented approach and by doing so provides a practical resource to guide the clinician through the options available.

Cardiac Biomarkers discusses how to use these biomarkers optimally and, in particular, how to understand when values provide actionable information. The book an essential guide for all physicians and healthcare practitioners in the field of cardiology.

Autorentext

Alan S. Maisel is a Professor of Medicine at the University of California, San Diego (UCSD). He is the Director of the Coronary Care Unit and Heart Failure Program at the VA San Diego Healthcare System in La Jolla, California. Dr. Maisel is active on the faculty at UCSD where he has won numerous teaching awards. Dr Maisel is considered one of the world's experts on cardiac biomarkers and has over 300 scientific publications. He has authored several ground-breaking publications that have paved the way for development of diagnostic tools for patients with congestive heart failure. In particular, he was the leading investigator on studies that brought the use of BNP into clinical practice. Dr Maisel is also a writer of medical fiction. His first novel, Bedside Manners was optioned to Warner Brothers. His second novel, Brain Chicane, is about a young and idealistic physician working at the premier multiple-organ transplant hospital in Chicago where he investigates overdose cases that are not totally kosher. Allan Jaffe is Professor of Medicine and Professor of Laboratory Medicine and Pathology and Chair of the Division of Core Clinical Laboratory Services at Mayo. He continues as an active clinician in the CCU. Dr. Jaffe has national and international repute for his work in cardiac biomarkers and co-ordinates the Biochemistry group of the taskforce for the Universal Definition of AMI. He is on the editor boards of most of the major cardiology journals and the most prestigious laboratory medicine one (Clinical Chemistry) as well. He has over 500 publications, mostly in the field of biomarkers and cardiac troponin.

Zusammenfassung
This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know.
The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.

Inhalt
The patient with chest pain: The troponin story.- Troponin Basics for the clinician.- Pathophysiology of trop I and T in myocardial ischemia/infarction.- International Definition of MI- rationale and practice.- Evaluation of patients presenting with chest pain- where do troponins fit in.- Using contemporary troponin in patients with AMI.- Using troponins to guide therapy in ACS.- Use of cTn in patients with heart failure.- Elevated cTn in other acute situations.- Use of cTn for detection of more chronic disease states.- High sensitivity assays- what are they and why do we need them.- Use of troponin for the evaluation of patients potentially at risk for cardiovascular disease.- Gaps in our biomarker armamentarium what novel biomarkers might be synergistic in patients with acute disease.- The patient with shortness of breath: the natriuretic peptide story.- Evaluation of patients presenting with sob- where do nps fit in.- Pathophysiology of bnp, and ntpro bnp.- A clinicians guide to lab assays for nps.- Using NPS in the ED- diagnosis.- Using NPs in the ED- algorithms and risk stratification.- Using NPs in the hospital.- NPs at the time of discharge.- Finger stick NP levels at home.- Guiding therapy of heart failure with NPs.- Caveats to NP measurement.- Other biomarkers for heart failure.- Biomarkers of cardiorenal disease,- Biomarkers of cardiac risk.