Biomechanics in Oncology

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology.

This book also:

Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy

Includes insight into NCIs' role in supporting biomechanics in oncology research

Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Autorentext

Cheng Dong is Distinguished Professor and Department Head of the Department of Biomedical Engineering at Pennsylvania State University.

Nastaran Zahir is Associate Director of the Division of Cancer Biology and Program Director of the Physical Sciences-Oncology Initiative at the National Cancer Institute.

Konstantinos Konstantopoulos is Professor of the Department of Chemical & Biomolecular Engineering at Johns Hopkins University.

Inhalt
Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer.- Traction Force Microscopy for Non-Invasive Imaging of Cell Forces.- Non-Invasive Imaging: Brillouin Confocal Microscopy.- Exposing Cell-itary Confinement: Understanding The Mechanisms Of Confined Single Cell Migration.- Modeling Cell Migration Mechanics.- Engineered models of metastasis with application to study cancer biomechanics.- Microenvironment influences cancer cell mechanics from tumor growth to metastasis.- From Cancer Immunoediting to New Strategies in Cancer Immunotherapy: The Roles of Immune Cells and Mechanics in Oncology.- Biomechanics of the circulating tumor cell microenvironment.- Mechanics of the cell nucleus.- Mechanical Forces in Tumor Angiogenesis.- DNA Mechanics and Topology.- Design of Fiber Networks for Studying Metastatic Invasion.- Extracellular matrix stiffness exists in a feedback loop that drives tumor progression.- Platelet-Based Drug Delivery for Cancer Applications.- The National Cancer Institute Investment in Biomechanics in Oncology Research.