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Biology of Inositols and Phosphoinositides

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This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in ... Weiterlesen
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This volume describes the current status of the biology of inositols and phosphoinositides with an emphasis on the development in the area since the publication of volume 26 in 1996 in this series. The progress made in dissecting the genetics, structure and evolution of the seminal enzyme for synthesis of inositol in the biological system has driven the understanding of the enzyme forward. With the current genomic and proteomic tools in place the new role of inositols, inositol phosphates and phosphoinositides in cell signaling or stress response has been explored. These advances are described in this volume and are expected to give new insights into the functional implications of inositol compounds across evolutionary diverse species.

From being to becoming important, myo-inositol and its derivatives including phosphoinositides and phosphoinositols involved in diversi?ed functions in wide varieties of cells overcoming its insigni?cant role had to wait more than a century. Myo-inositol, infact, is the oldest known inositol and it was isolated from muscle as early as 1850 and phytin (Inositol hexakis phosphate) from plants by Pfeffer in 1872. Since then, interest in inositols and their derivatives varied as the methodology of isolation and puri?cation of the stereoisomers of inositol and their derivatives advanced. Phosphoinositides were ?rst isolated from brain in 1949 by Folch and their structure was established in 1961 by Ballou and his coworkers. After the compilation of scattered publications on cyclitols by Posternak (1965), proceedings of the conference on cyclitols and phosphoinositides under the supervision of Hoffmann-Ostenhof, were p- lished in 1969. Similar proceedings of the second conference on the same s- ject edited by Wells and Eisenberg Jr was published in 1978. In that meeting at the concluding session Hawthorne remarked persued deeply enough p- haps even myoinositol could be mirror to the whole universe. This is now infact the scenario on the research on inositol and their phosphoderivatives. Finally a comprehensive information covering the aspects of chemistry, b- chemistry and physiology of inositols and their phosphoderivatives in a book entitled Inositol Phosphates written by Cosgrove (1980) was available.

Chapter 1: Structure and Nomenclature of Inositol Phosphates, Phosphoinositides, and Glycosylphospatidylinositols, Pushpalatha P.N. Murthy; Chapter 2: Inositol and Plant Cell Wall Polysaccharide Biogenesis Frank A. Loewus; Chapter 3: Functional Genomics of Inositol Metabolism Javad Torabinejad and Glenda E. Gillaspy; Chapter 4: Genetics of Inositol Polyphosphates Victor Raboy and David Bowen; Chapter 5: Inositol in Bacteria and Archaea, Mary F. Roberts; Chapter 6: Regulation of 1D-myo-inositol-3-phosphate synthase in yeast Lilia R. Nunez and Susan A. Henry; Chapter 7: The structure and mechanism of myo-inositol-1-phosphate synthase, James H. Geiger and Xiangshu Jin; Chapter 8: Phosphoinositide Metabolism: Towards an Understanding of Subcellular Signaling, Wendy F. Boss, Amanda J. Davis, Yang Ju Im, Rafaelo M. Galvn o and Imara Y. Perera; Chapter 9: Cracking the green paradigm: Functional coding of phosphoinositide signals in plant stress responses, Laura Zonia and Teun Munnik; Chapter 10: Inositols and their metabolites in abiotic and biotic stress responses, Teruaki Taji1,2, Seiji Takahashi3 and Kazuo Shinozaki1 ; Chapter 11: Inositol Phosphates and Phosphoinositides in Health and Disease, Yihui Shi, Abed N Azab, Morgan Thompson and Miriam L Greenberg; Chapter 12: Mammalian Inositol 3-phosphate Synthase: Its Role in the Biosynthesis of Brain Inositol and its Clinical Use as a Psychoactive Agent * Latha K. Parthasarathy, Ratnam S. Seelan, Carmelita R. Tobias, Manuel F. Casanova, and Ranga N. Parthasarathy, ; Chapter 13: Evolutinary divergence of L-myo-inositol-1-phosphate synthase: Significance of a 'Core catalytic structure' Krishnarup Ghosh Dastidar, Aparajita Chatterjee, Anirban Chatterjee and Arun Lahiri Majumder.


Titel: Biology of Inositols and Phosphoinositides
EAN: 9780387276007
ISBN: 978-0-387-27600-7
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Herausgeber: Springer
Genre: Biologie
Anzahl Seiten: 340
Veröffentlichung: 03.10.2006
Jahr: 2006
Untertitel: Englisch
Dateigrösse: 4.0 MB