Bisphosphonates in Clinical Oncology

This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology. The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as the results of pivotal studies. New important findings on how to best use pamidronate in certain indications are given and put in perspective. The author discusses patient management guidelines as well as pharmaco-economic aspects important for the readers.

Inhalt

Physiology and Pathophysiology of Bone.- Factors Regulating Calcium Hmomeostasis and Bone Resorption/Bone Formation.- Pharmacological Treatment of Bone Disorders.- Pamidronate.- Recent Developments and Future Directions.-