Chemical Ionization Mass Spectrometry

The only comprehensive guide to CIMS applications in structural elucidation and analytical studies

Chemical Ionization Mass Spectrometry, 2nd Edition, provides a comprehensive, up-to-date review of CIMS applications in structural elucidation and quantitative analytical studies. For the benefit of readers without a background in gaseous ion chemistry, a thorough review is presented in Chapter 2. Other chapters discuss such topics as reagent ion systems within the context of the thermochemistry and kinetics of the ionization process, including reactions and the type of information obtained; isotopic exchange reactions; stereochemical effects in chemical ionization; and reactive ion/molecule collisions in quadrupole cells. Chemical ionization mass spectra of 13 classes of compounds are discussed in detail to illustrate the influence of different functional groups on the spectra observed.

Chemical Ionization Mass Spectrometry, 2nd Edition will be a valuable reference for anyone interested in mass spectrometry and gaseous ion chemistry in general.

Autorentext

Harrison, Alex. G.

Inhalt

INTRODUCTION. PREFACE. MOLECULAR MASS DETERMINATION. STRUCTURE ELUCIDATION. IDENTIFICATION AND QUANTITATION. SCOPE OF THE PRESENT WORK. FUNDAMENTALS OF GAS PHASE ION CHEMISTRY. ION/MOLECULE COLLISION RATES. Langevin Ion-Induced Dipole Theory. Average Dipole Orientation (ADO) Theory. POSITIVE ION/MOLECULE REACTIONS. Charge Exchange. Proton and Hydrogen Atom Transfer. Negative Ion Transfer Reactions. Condensation Reactions. Clustering or Association Reactions. NEGATIVE ION/MOLECULE REACTIONS. Electron/Molecule Interactions. Associative Detachment Reactions. Displacement and Elimination Reactions. Proton Transfer Reactions. Charge Exchange Reactions. Association Reactions. THERMOCHEMICAL PROPERTIES OF GAS-PHASE IONS. Gas Phase Basicities: Proton Affinities. Hydride Ion Affinities. Electron Affinities. Gas Phase Acidities: Proton Affinities of Anions. INSTRUMENTATION FOR CHEMICAL IONIZATION. MEDIUM PRESSURE MASS SPECTROMETRY. ATMOSPHERIC PRESSURE IONIZATION (API) MASS SPECTROMETRY. FOURIER TRANSFORM MASS SPECTROMETRY (FTMS). QUADRUPOLE ION TRAP MASS SPECTROMETRY. PULSED POSITIVE ION-NEGATIVE ION CHEMICAL IONIZATION. SAMPLE INTRODUCTION IN CHEMICAL IONIZATION MASS SPECTROMETRY. INSTRUMENTATION FOR COLLISION-INDUCED DISSOCIATION (CID) STUDIES. CHEMICAL IONIZATION REAGENT SYSTEMS. POSITIVE ION REAGENT SYSTEMS. Brønsted Acid Reagent Systems. Hydride Ion Abstraction Reagent Systems. Charge Exchange Reagent Systems. Condensation Reaction Reagents. NO as a Positive Ion Reagent System. Tetramethylsilane Reagent System. Metal Ion Reagent Systems. Miscellaneous Positive Ion Reagent Systems. NEGATIVE ION REAGENT GAS SYSTEMS. Electron Capture Reagent Systems. Brønsted Base Reagent Systems. 0- as a Reagent Ion. 02- as a Reagent Ion. SENSITIVITY OF CHEMICAL IONIZATION. CHEMICAL IONIZATION MASS SPECTRA. ALKANES (CnH2n+2). ALKENES AND CYCLOALKANES (CnH2n). ALKYNES, ALKADIENES, AND CYCLOALKENES (CnH2n-2). AROMATIC HYDROCARBONS. ALCOHOLS. ETHERS. ALDEHYDES AND KETONES. CARBOXYLIC ACIDS A