Population Genetics and Microevolutionary Theory

Population Genetics and Microevolutionary Theory

Explore the fundamentals of the biological implications of population genetic theory

In the newly revised Second Edition of Population Genetics and Microevolutionary Theory, accomplished researcher and author Alan R. Templeton delivers a fulsome discussion of population genetics with coverage of exciting new developments in the field, including new discoveries in epigenetics and genome-wide studies. The book prepares students to successfully apply population genetics analytical tools by providing a solid foundation in microevolutionary theory.

The book emphasizes that population structure forms the underlying template upon which quantitative genetics and natural selection operate and is a must-read for future population and evolutionary geneticists and those who wish to work in genetic epidemiology or conservation biology.

You'll learn about a wide array of topics, including quantitative genetics, the interactions of natural selection with other evolutionary forces, and selection in heterogeneous environments and age-structured populations. Appendices that cover genetic survey techniques and probability and statistics conclude the book.

Readers will also benefit from the inclusion of:

• A thorough introduction to population genetics, including the scope of the subject, its premises, and the Hardy-Weinberg Model of Microevolution
• An exploration of systems of mating, including a treatment of the use of runs of homozygosity to show pedigree inbreeding in distant ancestors
• A practical discussion of genetic drift, including the use of effective sizes in conservation biology (with a discussion of African rhinos as an example)
• A concise examination of coalescence, including a treatment of the infinite sites model

Perfect for graduate students in genetics and evolutionary biology programs and advanced undergraduate biology majors, Population Genetics and Microevolutionary Theory will also earn a place in the libraries of students taking courses in conservation biology, human genetics, bioinformatics, and genomics.

Autorentext

Alan R. Templeton, PhD, is Charles Rebstock Professor Emeritus of Biology and Statistical Genomics at Washington University in St. Louis. His research focus is on the application of molecular genetic techniques and statistical population genetics to a variety of basic and applied evolutionary problems. He is on the editorial boards of Molecular Phylogenetics and Evolution and Evolutionary Bioinformatics Online.

Zusammenfassung
Population Genetics and Microevolutionary Theory Explore the fundamentals of the biological implications of population genetic theoryIn the newly revised Second Edition of Population Genetics and Microevolutionary Theory, accomplished researcher and author Alan R. Templeton delivers a fulsome discussion of population genetics with coverage of exciting new developments in the field, including new discoveries in epigenetics and genome-wide studies. The book prepares students to successfully apply population genetics analytical tools by providing a solid foundation in microevolutionary theory.The book emphasizes that population structure forms the underlying template upon which quantitative genetics and natural selection operate and is a must-read for future population and evolutionary geneticists and those who wish to work in genetic epidemiology or conservation biology.You'll learn about a wide array of topics, including quantitative genetics, the interactions of natural selection with other evolutionary forces, and selection in heterogeneous environments and age-structured populations. Appendices that cover genetic survey techniques and probability and statistics conclude the book.Readers will also benefit from the inclusion of:

• A thorough introduction to population genetics, including the scope of the subject, its premises, and the Hardy-Weinberg Model of Microevolution
• An exploration of systems of mating, including a treatment of the use of runs of homozygosity to show pedigree inbreeding in distant ancestors
• A practical discussion of genetic drift, including the use of effective sizes in conservation biology (with a discussion of African rhinos as an example)
• A concise examination of coalescence, including a treatment of the infinite sites modelPerfect for graduate students in genetics and evolutionary biology programs and advanced undergraduate biology majors, Population Genetics and Microevolutionary Theory will also earn a place in the libraries of students taking courses in conservation biology, human genetics, bioinformatics, and genomics.

Inhalt
Preface to the 2nd Edition ix

Chapter 1. The Scope and Basic Premises of Population Genetics 1-1

Basic Premises of Population Genetics 1-1

Population Genomics1-12

Section 1: Population Structure and History

Chapter 2. Modeling Evolution and the Hardy-Weinberg Law 2-1

How to Model Microevolution 2-1

The Hardy-Weinberg Model 2-4

Hardy-Weinberg for Two Loci2-19

Chapter 3. Systems of Mating 3-1

Inbreeding 3-1

Assortative Mating3-25

Disassortative Mating3-45

Chapter 4. Genetic Drift 4-1

Basic Evolutionary Properties of Genetic Drift 4-2

Founder and Bottleneck Effects 4-7

Genetic Drift and Disequilibrium4-11

Genetic Drfit, Disequilibrium, and System of Mating4-13

Effective Population Size4-18

Chapter 5. Genetic Drift in Large Populations and Coalescence 5-1

Newly Arisen Mutations 5-1

Neutral Alleles 5-3

The Coalescent5-22

Chapter 6. Gene Flow and Population Subdivision 6-1

Gene Flow Between Two Local Populations 6-1

The Balance of Gene Flow and Drift 6-6

An Example of the Balance of Drift and Gene Flow6-27

Factors Influencing The Amount and Patter of Gene Flow6-42

Total Effective Population Size in Subdivided Populations6-62

Multiple Modes of Inheritance and Population Structure6-71

Admixture6-76

Identifying Subpopulations and Population Structure6-81

A Final Warning6-96

Chapter 7. Population History 7-1

Inferring Historical Effective Population Sizes 7-6

Inferring Historical Gene Flow Patterns and Admixture 7-11

Using Haplotype Trees to Study Population History 7-19

Model Based Approaches to Phylogeographic Analysis 7-56

Direct Studies Over Space and Past Times 7-70

Historical Population Genetics and Macroevolution 7-75

Section 2: Genotype and Phenotype

Chapter 8. Basic Quantitative Genetic Definitions and Theory 8-1

Simple Mendelian Phenotypes 8-2

Nature Versus Nurture? 8-7

The Fisherian Model of Quantitative Genetics8-13

Chapter 9. Quantitative Genetics: Unmeasured Genotypes 9-1

Correlation Between Relatives 9-2

The Distinction Between Heritability and Inheritance9-17

Response to Selection9-19

The Problem of Between-Population Differences in Mean

Phenotype 9-21

Controlled Crosses for the Analysis of Between Population

Differences 9-30

The Balance Between Mutation, Drift, and Gene Flow Upon

Phenotypic Variance 9-36

Chapter 10. Quantitative Genetics: Measured Genotypes 10-1

Marker Association Studies 10-5

Candidate Loci10-35

Candidate Loci and Genetic Architecture10-51

Section 3: Natural Selection and Adaptation

Chapter 11. Natural Selection 11-1

The Fundamental Equation of Natural Selection: Measured

Genotypes 11-4

Sickle-Cell Anemia as an Example of Natural Selection 11-10

Adaptation as a Polygenic Process 11-24

The Fundamental Theorem of Natural Selection: Unmeasured

Genotypes 11-29

Some Implications of the Fundamental Equations of Natural

Selection 11-33

The Course of Adaptation and Natural Selection 11-47

Chapter 12. Interactions of Natural Selection with Other Evolutionary Forces

and the Detection of Natural Selection 12-1

The Interaction of Natural Selection with Mutation 12-3…