Advances in Malignant Hematology

This comprehensive book captures and compiles new and current information on hematologic malignancies. New knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic and genomic changes has influenced the current outlook toward haematological malignancies. This recent and ongoing expansion of knowledge on malignant hematology has not previously been utilized to its full capacity due to its diffuse distribution scattered over the internet and research publications. This book is written by experts from the American and European continent, sharing their current thoughts and knowledge on the pathobiology of malignant haematological diseases of the blood, as well as current treatment strategies and future developments in the area of these haematological diseases.

Autorentext

Hussain I. Saba, Department of Medicine, University of South
Florida College of Medicine; James A. Haley Veterans Hospital; H.
Lee Moffitt Cancer Center and Research Institute; , Tampa, FL, USA

Ghulam Mufti, Department of Haematological Medicine,
Guy's and St. Thomas's School of Medicine, King's
College Hospital, London, UK

Klappentext
Advances in Malignant Hematology captures and compiles new and current information on hematologic malignancies. New knowledge of cellular disease processes, molecular pathology, and cytogenetic, epigenetic and genomic changes has influenced the current outlook toward malignant hematology. This recent and ongoing explosion of knowledge has not previously been captured and utilized to its full capacity due to its diffuse distribution over the internet and research publications. This comprehensive book is written by experts from the American and European continent, sharing their current thoughts and knowledge on the pathobiology of malignant hematological diseases, their current treatment strategies and future developments.

The book is divided into five sections:

• Hematopoiesis
• Myeloid Malignancies
• Lymphoid Malignancies
• Plasma Cell Disorders
• Bone Marrow Transplantation and Quality of Life
  There was a time when the practicing hematologist could only offer treatment for the symptoms of malignant disease states. Now, treatment attempts are being offered to attack and eradicate diseases at their molecular level. In some instances this has helped to achieve a near cure, and perhaps a complete cure in the near future, for some of the hematological malignancies.

Advances in Malignant Hematology provides significant help in the battle against hematologic cancer and will be valuable to hematologists in training and in practice.

Inhalt

Part 1: Hematopoiesis.

1 Normal and Malignant Hematopoiesis (Bijal D. Shah and
Kenneth S. Zuckerman).

2 The Leukemic Genome (Jonathan C. Strefford and Nicholas CP
Cross).

Part 2: Myeloid Malignancies.

3 Myeloproliferative Neoplasms (Ruben A. Mesa and Ayalew
Tefferi).

4 CML: Molecular Biology of BCR-Able (Javier I.
Pinilla-Ibarz, Eric Padron and Lori Hazlehurst).

5 Standard Management of Patients with CML (Chronic Myeloid
Leukemia) (Elias Jabbour, Jorge Cortes and Hagop
Kantarjian).

6 The Molecular Biology of Acute Myeloid Leukemia (Jerald
Radich).

7 Acute Myeloid Leukemia (Martin S. Tallman, Ritesh Parajuli
and Jessica K. Altman).

8 Acute promyelocytic leukemia (APL) (Sylvain Thépot,
Lionel Ades and Pierre Fenaux).

9 A Pluralistic approach to the study of myelodysplastic
syndromes: Evolving pathology of the Seed via the Soil (Naomi
Galili, Raymond Cruz, Jamie Stratton, Jessica Clima, Ghulam Sajjad
Khan and Azra Raza).

10 Myelodysplastic Syndrome: A Review of Current Care
(Kenneth H. Shain, Alan F. List and Rami S. Komrokji).

11 Supportive Care in Myelodysplastic Syndrome (MDS) (Hussain
I. Saba, Arshia A. Dangol and Donald C. Doll).

Part 3: Lymphoid Malignancies.

12 Molecular Biology of Chronic Lymphoproliferative Disorders
(Monique A. Hartley and Lubomir Sokol).

13 Chronic Lymphocytic Leukemia (Terry Hamblin and Angela
Hamblin).

14 Acute Lymphoblastic Leukemia (Susan O'Brien, Stefan
Faderl, Deborah Thomas and Hagop M.
Kantarjian).

15 Large Granular Lymphocyte Leukemia (Xin Liu and Thomas P.
Loughran, Jr.).

16 Hairy Cell Leukemia (Kevin T. Kim, Darren S. Sigal and
Alan Saven).

17 Molecular Basis of B-cell Lymphomas (Elizabeth M. Sagatys,
Eduardo M. Sotomayor and Jianguo Tao).

18 Non-Hodgkin's Lymphomas (Peter McLaughlin and Nathan
Fowler).

19 Hodgkin Lymphoma (Michael Crump).

Part 4: Plasma Cell Disorders.

20 Multiple Myeloma: Molecular Biology, Diagnosis and
Treatment (S. Vincent Rajkumar and Shaji Kumar).

21 Waldenström's Macroglobulinemia (Robert A. Kyle
and Suzanne Hayman).

22 Primary Systemic (AL) Amyloidosis (Efstathios Kastritis
and Meletios Athanasios Dimopoulos).

Part 5: Bone Marrow Transplantation and Quality of
Life.

23 Advances in allogeneic hematopoietic cell transplantation:
progress in transplantation technology and disease-specific
outcomes (Joseph Pidala and Claudio Anasetti).

24 Quality of Life after the diagnosis of Hematological
Malignancies (Mohamed Sorror).