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Alveolar Epithelial Repair in Gram Negative Bacterial Pneumonia

  • Kartonierter Einband
  • 88 Seiten
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Damaged alveolar barrier and impaired gas exchange are the major hallmarks of pulmonary infection. Consequently, epithelial repair... Weiterlesen
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Beschreibung

Damaged alveolar barrier and impaired gas exchange are the major hallmarks of pulmonary infection. Consequently, epithelial repair processes are initiated to restore the normal lung homeostasis. In the present thesis it was investigated whether early activated alveolar macrophages (AMf) contribute to alveolar epithelial repair following infection. LPS-activated AMf stimulated alveolar epithelial cells (AEC) to express growth factors, particularly GM-CSF in co-culture, in a TNF-alpha dependent manner. GM-CSF in turn elicited autocrine proliferative signalling in AEC. Notably, intra-alveolar TNF-alpha neutralization impaired AEC proliferation in LPS-injured mice in vivo. GM-CSF-deficient mice displayed reduced AEC proliferation and sustained alveolar barrier dysfunction upon LPS injury. Similarly, K. pneumoniae lung infection resulted in early release of macrophage TNF-alpha and epithelial GM-CSF, and subsequent TNF- -dependent AEC proliferation during alveolar repair. These findings indicate that TNF-alpha from activated AMf induces epithelial GM-CSF expression, which in turn initiates AEC proliferation and thus contributes to restore alveolar barrier function.

Autorentext

Born 1980 Macedonia; 1998-2003 Faculty of Pharmacy, University of Skopje "Design of novel thrombin inhibitors"; 2004-2005 Pharmacutical company Alkaloid-Skopje; 2005-2009 PhD Studies, Justus-Liebig Univeristy Giessen, Germany "Macrophage-epithelial crosstalk during alveolar repair"; From September 2009 Postdoc at Rudolf-Virchow-Zentrum, Würzburg

Produktinformationen

Titel: Alveolar Epithelial Repair in Gram Negative Bacterial Pneumonia
Untertitel: Macrophage-epithelial crosstalk during alveolar epithelial repair following pathogen-induced pulmonary inflammation
Autor:
EAN: 9783838111865
ISBN: 978-3-8381-1186-5
Format: Kartonierter Einband
Herausgeber: Südwestdeutscher Verlag für Hochschulschriften AG
Genre: Allgemeines & Lexika
Anzahl Seiten: 88
Gewicht: 147g
Größe: H220mm x B150mm x T5mm
Jahr: 2015

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