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High-Performance Computational Modeling of Tissue Growth Processes

  • Kartonierter Einband
  • 308 Seiten
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This work presents a comprehensive high-performance 3D computer model simulating complex tissue growth processes. The model contai... Weiterlesen
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Beschreibung

This work presents a comprehensive high-performance 3D computer model simulating complex tissue growth processes. The model contains three major components: (a) a discrete algorithm simulating individual cell activities and cell-cell interactions; (b) transient partial differential equations (PDE''s) describing the convection, diffusion, consumption and secretion of nutrients, growth factors or other important substances in tissue systems; and (c) rules describing how cell behavior is modulated by the local concentrations of nutrients and growth factors. The discrete model captures the essential features of important cellular activities including migration, proliferation and cell-cell contact. The diffusion-reaction PDE''s are discretized with an implicit-explicit scheme and the resulting linear systems are solved with a highly efficient GMRES solver. The model is fully parallelized for execution on distributed-memory computer clusters. Simulation results reveal the intricate interplay of cell population and mass transfer dynamics during the growth of various tissues, such as bioartificial tissues and tumors.

Produktinformationen

Titel: High-Performance Computational Modeling of Tissue Growth Processes
Untertitel: Insights on the Interplay of Cell Population and Mass Transfer Dynamics
Autor:
EAN: 9783836465397
ISBN: 978-3-8364-6539-7
Format: Kartonierter Einband
Herausgeber: VDM Verlag
Genre: Sonstiges
Anzahl Seiten: 308
Gewicht: 475g
Größe: H222mm x B151mm x T22mm
Veröffentlichung: 01.04.2008
Jahr: 2008

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