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Conjugated Linoleic Acid Reduces Inflammation in Animal Models

  • Kartonierter Einband
  • 164 Seiten
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Conjugated linoleic acid (CLA) isomers are naturally occurring dietary fatty acids derived primarily from microbial biohydrogenati... Weiterlesen
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Beschreibung

Conjugated linoleic acid (CLA) isomers are naturally occurring dietary fatty acids derived primarily from microbial biohydrogenation of linoleic acid. Commercially synthesized dietary CLA supplements (predominantly equal parts c9, t11 and t10, c12 CLA) were shown to alleviate clinical signs of inflammatory diseases such as atherosclerosis, lupus, type I airway hypersensitivity, endotoxin induced cachexia, and models of inflammatory bowel disease. Potential anti-inflammatory properties of CLA may be attributable to its regulation of TNF and inducible cyclooxygenase (COX-2) via signaling pathways for TNF and COX-2 such as peroxisome proliferator-activated receptor ? (PPAR?), nuclear factor-kappaB (NF-?B), and MAP Kinase. This work explores molecular mechanisms of CLA''s action of inflammation and associated signaling pathways through in vivo experimentation in various models of inflammation as well as analysis of signaling pathways at the molecular level. In particular we have utilized the murine collagen induced and collagen antibody induced arthritis models of rheumatoid arthritis, and the endotoxic shock model of the severe systemic inflammatory response. Our hypotheses have been derived from the concept that dietary CLA is a stable structural analog of the pro-inflammatory nutrient linoleic acid, and thus may exert anti-inflammatory actions.

Produktinformationen

Titel: Conjugated Linoleic Acid Reduces Inflammation in Animal Models
Untertitel: Evidence of a Molecular Mechanism
Autor:
EAN: 9783836461931
ISBN: 978-3-8364-6193-1
Format: Kartonierter Einband
Herausgeber: VDM Verlag Dr. Müller e.K.
Genre: Sonstiges
Anzahl Seiten: 164
Gewicht: 263g
Größe: H220mm x B150mm x T15mm
Jahr: 2013